ScienceOpen:
research and publishing network
For Publishers
Discovery
Metadata
Peer review
Hosting
Publishing
For Researchers
Join
Publish
Review
Collect
My ScienceOpen
Sign in
Register
Dashboard
Blog
About
Search
Advanced search
My ScienceOpen
Sign in
Register
Dashboard
Search
Search
Advanced search
For Publishers
Discovery
Metadata
Peer review
Hosting
Publishing
For Researchers
Join
Publish
Review
Collect
Blog
About
3
views
0
references
Top references
cited by
2
Cite as...
0 reviews
Review
0
comments
Comment
0
recommends
+1
Recommend
0
collections
Add to
0
shares
Share
Twitter
Sina Weibo
Facebook
Email
997
similar
All similar
Record
: found
Abstract
: not found
Book
: not found
Blood-Brain Barrier in Drug Discovery : Optimizing Brain Exposure of CNS Drugs and Minimizing Brain Side Effects for Peripheral Drugs
edited_book
Editor(s):
Li Di
,
Edward H. Kerns
Publication date
(Print):
January 30 2015
Publisher:
John Wiley & Sons, Inc
Read this book at
Publisher
Buy book
Review
Review book
Invite someone to review
Bookmark
Cite as...
There is no author summary for this book yet. Authors can add summaries to their books on ScienceOpen to make them more accessible to a non-specialist audience.
Related collections
Future Drug Discovery
Author and book information
Book
ISBN (Electronic):
9781118788523
ISBN (Print):
9781118788356
Publication date (Print):
January 30 2015
DOI:
10.1002/9781118788523
SO-VID:
33045c23-197b-4d70-bdea-91c174da1e78
History
Data availability:
Comments
Comment on this book
Sign in to comment
Book chapters
pp. a1
Supplementary Images
pp. i
Front Matter
pp. 1
Introduction and Overview
pp. 5
Pharmacokinetics of CNS Penetration
pp. 42
Free Drug Hypothesis for CNS Drug Candidates
pp. 66
Species Differences and Impact of Disease State on BBB
pp. 95
Passive Diffusion Permeability of the BBB-Examples and SAR
pp. 113
Establishment of P-Glycoprotein Structure-Transport Relationships to Optimize CNS Exposure in Drug Discovery
pp. 125
Uptake Transport at the BBB-Examples and SAR
pp. 146
Transport of Protein and Antibody Therapeutics Across the Blood-Brain Barrier
pp. 167
In SilicoTools for Predicting Brain Exposure of Drugs
pp. 188
In VitroAssays for Assessing BBB Permeability
pp. 238
Human-BasedIn VitroBrain Endothelial Cell Models
pp. 274
Methods for Assessing Brain Binding
pp. 284
In VivoStudies of Brain Exposure in Drug Discovery
pp. 296
PBPK Modeling Approach for Predictions of Human CNS Drug Brain Distribution
pp. 324
PK/PD Modeling of CNS Drug Candidates
pp. 351
Microdialysis to Assess Free Drug Concentration in Brain
pp. 365
Imaging Techniques for Central Nervous System (CNS) Drug Discovery
pp. 385
Designing CNS Drugs for Optimal Brain Exposure
pp. 425
Case Studies of CNS Drug Optimization-Medicinal Chemistry and CNS Biology Perspectives
pp. 446
Designing Peripheral Drugs for Minimal Brain Exposure
pp. 463
Case Studies of Non-CNS Drugs to Minimize Brain Penetration-Nonsedative Antihistamines
pp. 483
Case Study 1
pp. 505
Case Study 2
pp. 521
Brain Delivery Using Nanotechnology
pp. 535
Intranasal Delivery to the Central Nervous System
pp. 567
Future Perspectives
pp. 580
Index
Similar content
997
Weaning management of newly received beef calves with or without continuous exposure to a persistently infected bovine viral diarrhea virus pen mate: Effects on health, performance, bovine viral diarrhea virus titers, and peripheral blood leukocytes 1
Authors:
J T Richeson
,
E Kegley
,
J Powell
…
Cyclic RGD-linked polymeric micelles for targeted delivery of platinum anticancer drugs to glioblastoma through the blood-brain tumor barrier.
Authors:
Mitsunobu R. Kano
,
Kazunori Kataoka
,
Nobuhiro Nishiyama
…
Effects of maternal smoking and exposure to methylmercury on brain-derived neurotrophic factor concentrations in umbilical cord serum.
Authors:
Outi Nikkilä
,
Philippe Grandjean
,
Eero Castrén
…
See all similar
Cited by
2
Circadian Rhythms of the Blood-Brain Barrier and Drug Delivery
Authors:
Mari Kim
,
Richard F. Keep
,
Shirley L. Zhang
On the quest of reliable 3D dynamic in vitro blood-brain barrier models using polymer hollow fiber membranes: Pitfalls, progress, and future perspectives
Authors:
Marián Mantecón-Oria
,
María J. Rivero
,
Nazely Diban
…
See all cited by