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      Health and Inequality 

      The Developmental Origins of Health Inequality

      edited-book
      Emerald Group Publishing Limited
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          Epigenetic programming by maternal behavior.

          Here we report that increased pup licking and grooming (LG) and arched-back nursing (ABN) by rat mothers altered the offspring epigenome at a glucocorticoid receptor (GR) gene promoter in the hippocampus. Offspring of mothers that showed high levels of LG and ABN were found to have differences in DNA methylation, as compared to offspring of 'low-LG-ABN' mothers. These differences emerged over the first week of life, were reversed with cross-fostering, persisted into adulthood and were associated with altered histone acetylation and transcription factor (NGFI-A) binding to the GR promoter. Central infusion of a histone deacetylase inhibitor removed the group differences in histone acetylation, DNA methylation, NGFI-A binding, GR expression and hypothalamic-pituitary-adrenal (HPA) responses to stress, suggesting a causal relation among epigenomic state, GR expression and the maternal effect on stress responses in the offspring. Thus we show that an epigenomic state of a gene can be established through behavioral programming, and it is potentially reversible.
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            Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults

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              On the Concept of Health Capital and the Demand for Health

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                Author and book information

                Book Chapter
                December 30 2013
                August 21 2014
                : 285-309
                10.1108/S1049-2585(2013)0000021025
                57c01254-5f3c-4a2b-9092-a019d64409ec
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