Artificial neural networks (ANN) are often more suitable for classification problems. Even then, training of ANN is a surviving challenge task for large and high dimensional natured search space problems. These hitches are more for applications that involves process of fine tuning of ANN control parameters: weights and bias. There is no single search and optimization method that suits the weights and bias of ANN for all the problems. The traditional heuristic approach fails because of their poorer convergence speed and chances of ending up with local optima. In this connection, the meta-heuristic algorithms prove to provide consistent solution for optimizing ANN training parameters. This chapter will provide critics on both heuristics and meta-heuristic existing literature for training neural networks algorithms, applicability, and reliability on parameter optimization. In addition, the real-time applications of ANN will be presented. Finally, future directions to be explored in the field of ANN are presented which will of potential interest for upcoming researchers.