0
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: not found
      • Book Chapter: not found
      Neuroendocrinology of Reproduction 

      Experimental Analysis of Hormone Actions on the Hypothalamus, Anterior Pituitary, and Ovary

      Springer US

      Read this book at

      Buy book Bookmark
          There is no author summary for this book yet. Authors can add summaries to their books on ScienceOpen to make them more accessible to a non-specialist audience.

          Related collections

          Most cited references 222

          • Record: found
          • Abstract: not found
          • Article: not found

          Atlas of estradiol-concentrating cells in the central nervous system of the female rat.

           D Pfaff,  M Keiner (1973)
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Surgical disconnection of the medial basal hypothalamus and pituitary function in the rhesus monkey. I. Gonadotropin secretion.

             Amy Butler,  L Krey,  E. Knobil (1975)
            In an intial attempt to localize the central components of the neuroendocrine control systems whereby estrogens regulate gonadotropin secretion, the medial basal hypothalamus (MBH) was surgically isolated from the remainder of the brain in 18 female rhesus monkeys using a modified "Halasz knife". The completeness and localization of the resulting "cuts" were verified by examinations of serial 50 mugM coronal sections through each hypothalamus. The cuts extended from the optic chiasm to the mamillary bodies and from midline to the medial aspects of the optic tracts. The MBH "ISLANDS" ISOLATED BY THESE CUTS INCLUDED THE MEDIAN EMINENCE AND ARCUATE NUCLEI AS WELL AS PORTIONS OF THE VENTROMEDIAL NUCLEI, PREMAMILLARY AREAS AND MAMILLARY BODIES. Following complete MBH isolation, 6 of 7 otherwise intact monkeys responded to an estradiol benzoate (EB) injection with large LH and FSH surges. Three of these animals also displayed spontaneous gonadotropin surges which eventuated in ovulation as evidenced by sustained elevations in circulating progesterone levels. Similar patterns of LH and FSH secretion in response to EB administration were also observed in 6 of 7 intact animals in which only the superofrontal imputs to the MBH WERE INTERRUPTED. Four of these monkeys ovulated spontaneously. Circulating gonadotropin levels fell slightly in ovariectomized monkeys following complete MBH disconnection, but the circhoral, pulsatile rhythms of gonadotropin release persisted. These animals also responded to the negative and positive feedback actions of estrogen as evidenced by initial declines in circulating LH and FSH concentrations followed by surges of these hormones at the appropriate times following the injection of EB. It would appear from these observations that the sites of the negative and positive feedback actions of estrogen on LH and FSH secretion and, therefore, the sites of the central components of the neuroendocrine systems which control tonic and surge secretion of the gonadotropic hormones in the rhesus monkey may be resident within the MBH-hypophysial unit.
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Ovarian follicular development in the rat: hormone receptor regulation by estradiol, follicle stimulating hormone and luteinizing hormone.

              The effects of estradiol, FSH and LH on ovarian follicular development and granulosa cell differentiation were examined in the immature rat hypophysectomized on day 24 of age. Administration of estradiol to hypophysectomized rats for 4 days stimulated the growth of large preantral follicles with a concomitant 1.5-fold increase in FSH receptor content and a 4-fold decrease in LH receptor content in the granulosa cells. When highly purified hFSH was administered alone, receptor content for FSH increased progressively for 4 days while receptor for LH remained essentially unchanged. However, when rats were pretreated with estradiol, the response of follicles to FSH was markedly enhanced as indicated by the appearance of large, antral follicles and elevated receptor content for both FSH and LH. Receptor content for FSH increased markedly in response to hFSH following only one day of estradiol pretreatment, while receptor content for LH increased most rapidly in response to hFSH after 3 days of estradiol pretreatment. LH administered to rats possessing large preovulatory follicles caused luteinization of granulosa cells and a marked decline in receptor content for both gonadotropins within 24 h. Receptor content remained low even 48 h after LH administration when granulosa cells were fully luteinized. These results indicated that follicular development and granulosa cell differentiation are dependent on steroid-protein hormone regulation of hormone specific receptors.
                Bookmark

                Author and book information

                Book
                978-1-4684-3883-3
                978-1-4684-3881-9
                1981
                10.1007/978-1-4684-3881-9
                Book Chapter
                1981
                : 243-278
                10.1007/978-1-4684-3881-9_9

                Comments

                Comment on this book

                Book chapters

                Similar content 3,332