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      Activated Charcoal in Medical Applications, Second Edition 

      Resins and Clays as Sorbents

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      CRC Press

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          Treatment of chlordecone (Kepone) toxicity with cholestyramine. Results of a controlled clinical trial.

          Industrial workers exposed to the organochlorine pesticide, chlordecone (Kepone), had signs of toxicity in several organs. The extent of toxicity was proportional to the levels of this chemical in the tissues. In 22 patients, chlordecone was eliminated slowly from blood (half time of 165 +/- 27 days--mean +/- S.E.M.) and fat (half time of 125 days, with a range of 97 to 177), chiefly in the stool. Output of chlordecone in bile was 10 to 20 times greater than in stool, suggesting that chlordecone is reabsorbed in the "ntestine. Cholestyramine, an anion-exchange resin that binds chlordecone, increased its fecal excretion by seven times. In a five-month trial, cholestyramine significantly accelerated elimination of chlordecone from blood, with a half life of 80 +/- 4 days (S.E.M.) (P less than 0.005) and fat (half life of 64 days, with a range of 52 to 85) (P less than 0.05). Cholestyramine offers a practical means for detoxification of persons exposed to chlordecone and possibly to other lipophilic toxins.
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            The Influence of Temperature and Time on the Adsorption of Paraquat, Diquat, 2,4-D and Prometone by Clays, Charcoal, and an Anion-Exchange Resin

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              Reduction of absorption of paracetamol by activated charcoal and cholestyramine: a possible therapeutic measure.

              The absorption of an oral 2-g dose of paracetamol was markedly reduced by the simultaneous oral administration of either activated charcoal or cholestyramine but was only slightly reduced when the adsorbents were given 60 minutes after the paracetamol. Since the absorption of a larger dose of the drug will probably be slow, the administration of adsorbents may be of value even when delayed several hours.
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                Book Chapter
                January 20 1995
                April 16 2013
                : 491-524
                10.1201/b14201-23
                cee6b2cb-8b5a-48ab-89d6-d7110c75a79a
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