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Six-Membered Hetarenes with Two Identical Heteroatoms
Fragments Hetarene and C—C—C—C
other
Author(s):
N. Haider
,
W. Holzer
Publication date
(Online):
2004
Publisher:
Georg Thieme Verlag KG
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Book Chapter
Publication date (Print):
2004
Publication date (Online):
2004
Page
: 1
DOI:
10.1055/sos-SD-016-00461
SO-VID:
df04dbd5-a9e1-4bf4-9c94-38aa13753708
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Book chapters
pp. 1
Pyrido[4,3-]pyrimidines
pp. 1
By [4 + 2]-Cycloaddition Reactions of 1,2,4,5-Tetrazines
pp. 1
N-Alkylation
pp. 1
Halogenation of Pyrazinols
pp. 1
Synthesis by Ring Transformation
pp. 1
Fragments C—C, C—C, and Two N Fragments
pp. 1
From 1,2-Diiodo-4-nitrobenzene and a Tellurium–Copper Reagent
pp. 1
Intramolecular Cyclization of Hydrazides and Hydrazones
pp. 1
With Formamide
pp. 1
Of 1,5-Benzodiazocines
pp. 1
By Formation of One N—C and One C—C Bond
pp. 1
Reaction of Resin-Bound 3-Arylacrylates with Amidine Derivatives
pp. 1
From Pyrido[4,3-]pyrimidines
pp. 1
Reaction of Phenylacetonitrile
pp. 1
By Formation of Two Te—C Bonds
pp. 1
Modification of Alkyl Substituents
pp. 1
From 2-(Acylamino)benzoic Acid Derivatives and Ammonia
pp. 1
By Lithiation
pp. 1
Condensation of 2-Halonitrobenzenes
pp. 1
By Self-Condensation
pp. 1
By [4 + 2]-Cycloaddition Reactions of Pyridazino[4,5-]pyridazines with Electron-Rich C—C Dienophiles
pp. 1
Reaction of 3-Aminoacrylamides with Acid Derivatives
pp. 1
From 2-Aminophenyl Ketones or 2-Aminobenzaldehydes and Urea, Carbamates, Guanidine, Imidates, or Carboxamides
pp. 1
Of Pteridines
pp. 1
Reaction of 1,3-Diketimines with Benzonitrile
pp. 1
Deoxygenation of Quinoxaline 1-Oxides and Quinoxaline 1,4-Dioxides
pp. 1
By Formation of One Se—Se Bond
pp. 1
Cyclocondensation of 4-Chloropyridazine-3-carbonyl Chloride with Enamines
pp. 1
Photolysis of Mesoionic Compounds
pp. 1
Formation of a Sulfonium Salt
pp. 1
Synthesis by Ring Transformation
pp. 1
Reaction of Cyanothioacetamide with Benzoyl Isothiocyanate
pp. 1
Of Heteroatoms
pp. 1
Dibenzo[,][1,4]dioxins from 2-Halophenols by Base-Induced Self-Condensation
pp. 1
Telluranthrenes from 1,2-Diiodobenzene Derivatives and Tellurium
pp. 1
Removal of Heterofunctional Groups from Hydro Precursors
pp. 1
Condensation of Pyrimidin-4-amines with a Three-Carbon Synthon
pp. 1
Fragments C—C, C—C, and Two S Fragments
pp. 1
Cycloamination of N-Substituted 2-Aminonicotinates
pp. 1
Decarboxylation, Decyanation, and Debenzylation
pp. 1
Direct Introduction of Substituents by Nucleophilic Reactions
pp. 1
From Benzene-1,2-diamine and 1-Nitroso-2-naphthol
pp. 1
Fragments N—C—C—C and N—C
pp. 1
Cycloamination of 3-Isothiocyanatopyridine-2-carboxylates
pp. 1
From Ethane-1,2-diamine and Benzo-1,4-quinones
pp. 1
Thermolysis of 1,2,3-Thiadiazoles
pp. 1
Fragments N—C—N and C—C—C
pp. 1
Fragments N—C—C—N and C—C
pp. 1
Intramolecular Cyclization of Pyridinecarbohydrazides
pp. 1
From Benzene-1,2-diamines and α-Azido Carbonyl Compounds
pp. 1
Cyclization of 3-(Cyanomethylamino)pyridin-2-amines
pp. 1
Of Halogen
pp. 1
With Trialkylaluminum
pp. 1
Miscellaneous Reactions
pp. 1
By Formation of One N—C and One C—C Bond
pp. 1
-Alkyl-, -Alkenyl-, and -Alkynylpurines
pp. 1
From 1,4-Diazabutadienes
pp. 1
By Cyclodimerization of Azirines
pp. 1
Synthesis from 4-(Alkylamino)-4-oxobutanoic Acids and Thionyl Chloride
pp. 1
Addition of Sulfur to 6-Nitroperylo[1,12-]thiophene
pp. 1
From 1,2-Dicarbonyl Compounds or α-Bromo Ketones
pp. 1
With Sulfuryl Chloride
pp. 1
Aromatization
pp. 1
Intramolecular Cyclization of 6-Amino-5-(cyanoacetyl)uracils or 6-Amino-5-propenyluracils
pp. 1
Reaction of Furo[3,4-]pyridine-1,3-diones with Hydrazines
pp. 1
From Indazole Derivatives
pp. 1
Reaction of Amidinoacetamides with Formamide
pp. 1
Pyrimidopyridazines
pp. 1
By Diels–Alder Reaction
pp. 1
Cyclization of (2-Hydrazinophenyl)(hydroxy)acetic Acids (The Neber–Bossel Synthesis)
pp. 1
Introduction of an Oxygen Functionality
pp. 1
Dibenzo[,][1,4]dioxinamines by Reduction of Nitrodibenzo[,][1,4]dioxins
pp. 1
With N-Nucleophiles
pp. 1
From Arenes
pp. 1
Intramolecular Cyclization of (Phenylimino)acetaldehyde -Acetyloxime Derivatives
pp. 1
Use of 2-Oxo Aldehydes and Their Equivalents
pp. 1
By Formation of One O—C Bond
pp. 1
Synthesis of [1]Benzothieno[2′3′:5,6][1,2]dithiino[4,3][1]benzothiophene
pp. 1
Introduction of Alkyl and Carboxamide Groups by Radical Substitution
pp. 1
Additional Methods
pp. 1
Oxidation
pp. 1
From Dialkynyl Sulfides with Sodium Sulfide
pp. 1
Ring Transformation of Imidazoles
pp. 1
Modification of a Nitro Group
pp. 1
Intramolecular Cyclization of 5-Acylpyridazin-4-amines
pp. 1
Fragments Arene—C—C and N—N
pp. 1
Synthesis of 1,2-Dithiin-3,6-diyldimethanol
pp. 1
Reaction with a Toluene Dioxygenase
pp. 1
From 1,3,5-Triazines
pp. 1
Pyrazinopyridazines
pp. 1
Hydroxylation, Alkoxylation, and Sulfanylation
pp. 1
Fragments C—N—Arene—C and N
pp. 1
Metal-Catalyzed Coupling of 2-Bromo-1,4-benzodioxin with Organometallics
pp. 1
Metalation
pp. 1
By Palladium-Catalyzed Synthesis
pp. 1
From 4-{[(Hydroxyimino)methyl]amino}-2-(methylsulfanyl)pyrimidine-5-carbonitrile
pp. 1
By Formation of One N—C Bond
pp. 1
By Electrochemical Approach
pp. 1
Reaction of 4-(Dimethylamino)-1,3-diazabuta-1,3-dienes
pp. 1
Modification of Sulfur-Containing Groups
pp. 1
From Benzene-1,2-diamine and α-Methylsulfinyl Ketones
pp. 1
Modification of Amine Substituents
pp. 1
Substitution of Hydrogen
pp. 1
Intramolecular Cyclization of 3-(Acylamino)pyridine-4-carboxamides
pp. 1
Direct Alkylation and Arylation
pp. 1
Nitration Using Nitric(V) Acid and Sulfuric Acid
pp. 1
Synthesis of Tin Dithiolates from Ketones by Grignard Reaction
pp. 1
Oxidation of Dibenzo[,][1,2]dithiin with (+)-Percamphoric Acid
pp. 1
Thermolysis of 2-Alkyl-1,2-dihydro-1,3,5-triazines
pp. 1
By Annulation to an Arene
pp. 1
Synthesis by Ring-Closure Reactions
pp. 1
Cyclization of Benzaldehyde [2-(Trifluoromethyl)phenyl]hydrazones
pp. 1
Synthesis by Ring-Closure Reactions
pp. 1
From 3-Aminopyrazine-2-carbonitriles or -2-carboxylates and Guanidine, Amidines, or Isocyanates (Taylor Synthesis)
pp. 1
From 1,4-Diazabutadienes
pp. 1
Halogenation
pp. 1
Of the Heterocyclic Ring
pp. 1
Reaction of β-Diketones with Cyanamide
pp. 1
From a 1,2-Dicarbonyl Compound
pp. 1
Of Pyrido[2,3-]pyrimidines with a Hydrogenated Pyrimidine Ring
pp. 1
Additions of Grignard Reagents
pp. 1
Fragments C—C—Te—C—C and Te
pp. 1
Rearrangement of Substituents
pp. 1
With Diethoxymethyl Acetate
pp. 1
Fragments C—C, C—C, and Two Se Fragments
pp. 1
Of Nitrogen Functionalities
pp. 1
Cyclization of -(2-Cyanovinyl)imidamides
pp. 1
By Formation of One S—C and One C—C Bond
pp. 1
Hetero-Diels–Alder Reactions of 4-Vinylpyridine with Diazenes
pp. 1
Modification of Substituents
pp. 1
Fragment N—Arene—N—C—C
pp. 1
Condensation Reactions of 4,5-Disubstituted Pyridazines
pp. 1
Photolysis and Thermolysis of Benzothiodiazoles
pp. 1
Synthesis of Phenazine 5-Oxides
pp. 1
From Two Halosulfanylarenes
pp. 1
Pyrimidopyrimidines
pp. 1
Reduction of Quinoxaline -Oxides
pp. 1
From Phenyl Isothiocyanates and Dialkylcyanamides
pp. 1
Reaction with Alkynes
pp. 1
Thionation–Dimerization of 1,3-Dihydro-2-indol-2-one
pp. 1
Reaction of Malonates with Amidine Derivatives
pp. 1
From Benzene-1,2-diamines and 2-Oxopropanal Oxime
pp. 1
Synthesis by Substituent Modification
pp. 1
By Bromination
pp. 1
Reaction of 3-Amino-3-(methylsulfanyl)acrylates with Guanidine and Thiourea
pp. 1
Cyclization of Nicotinamides
pp. 1
By Iodination
pp. 1
From Fused Lactones or Thiolactones
pp. 1
Oxidative Dehydrazination of Hydrazinopyridazines
pp. 1
Fragment N—C—C—N—C—C
pp. 1
By Formation of One N—C Bond
pp. 1
From Furazano[3,4-]pyrimidines
pp. 1
Fragments Arene—C, N—C, and N
pp. 1
Direct Chlorination
pp. 1
Cyclization of -[2-(Methoxycarbonyl)ethylidene]ureas
pp. 1
Dibenzo[,][1,4]dioxins from 2-(2-Halophenoxy)phenolates
pp. 1
Cyclocondensation of 4-Oxopiperidine-3-acetates with Hydrazines
pp. 1
By 1,3-Dipolar Cycloaddition
pp. 1
Addition of Carbofunctional Groups
pp. 1
Cyclization of 3-Oxopiperidine-4-carboxylates and Related Compounds with Ureas or Amidines
pp. 1
Cyclization of Diazotized 2-(Alken-1-yl)anilines (The Widman–Stoermer Synthesis)
pp. 1
Aromatization
pp. 1
Reaction of 3-Amino-2-cyanoacrylamides with Anhydrides
pp. 1
Fragments N—C—C, C—C, and N
pp. 1
By Exchange of Chlorine for Fluorine
pp. 1
Quinoxalinethiones from the Corresponding Oxo Derivatives
pp. 1
Selenylation of an Organolithium Compound with Elemental Selenium
pp. 1
Fragments C—C—C—N and N—C
pp. 1
Condensation of Hydrazones with Malononitriles
pp. 1
By Ring Contraction
pp. 1
Modification of Substituents
pp. 1
From 2-Ureidophenyl Ketones or -(2-Acylphenyl) Amidines
pp. 1
By Addition of Diazoalkanes to Bromocyclopropenes
pp. 1
By Formation of Four N—C Bonds
pp. 1
By the Solid-Phase Approach
pp. 1
Oxidation of Purines with Destruction of the Aromatic System
pp. 1
Synthesis by Substituent Modification
pp. 1
Of Nitrogen Functionalities
pp. 1
Reaction of 2-(2-Phenylvinyl)-3-vinylthiirane Promoted by Acetonitrile(pentacarbonyl)tungsten(0)
pp. 1
Substitution of Amino Groups by Halogens and Hydroxy Groups
pp. 1
Reaction of 1,2,3,5-Oxathiadiazine 2,2-Dioxide with Active Methylene Compounds
pp. 1
Pyrazinopyrazines
pp. 1
By Formation of One N—C Bond
pp. 1
Cyclization with an Ortho Ester Alone
pp. 1
By Formation of Two N—C Bonds
pp. 1
At a Ring Nitrogen Atom of a Pyridazinone
pp. 1
Cyclization of ′,2-Dicyanoamidethanimide and 1,3-Diketones
pp. 1
Pyrido[4,3-]pyrimidines
pp. 1
Fragment N—C—C—N—C—C
pp. 1
By the Silyl-Hilbert–Johnson Reaction
pp. 1
Modification of Substituents
pp. 1
Oxidative Cyclization with Air
pp. 1
Reduction of Nitro Groups
pp. 1
Cyclization with Acids
pp. 1
Of Carboxylic Acids and Derivatives
pp. 1
Modification of Thioxo Groups
pp. 1
Substitution of Existing Substituents
pp. 1
Fragment C—N—C—N—Arene
pp. 1
By Deuterium or Metals
pp. 1
Of Hydrogen
pp. 1
Purines Reduced in the Pyrimidine Ring
pp. 1
Cycloamination of 3-Vinylpyridazine-4-carboxylates
pp. 1
By Ring Contraction
pp. 1
From 2-Aminobenzonitriles and Guanidines, Imidates, or Formimidamides
pp. 1
Decarboxylation
pp. 1
From Bis(2-lithioaryl) Sulfides
pp. 1
Intramolecular Cyclization of 4-(Cyanomethyl)pyrimidine-5-carbonitriles
pp. 1
From Isoindole Derivatives
pp. 1
Of Heteroatoms
pp. 1
From 1,2-Dithiones
pp. 1
Fragments N—C—C—N—C and C
pp. 1
From 2-Ureidobenzonitriles
pp. 1
Synthesis from an Oxadiazole Ring
pp. 1
Substitution of Carbon Functionalities
pp. 1
From 4-3,1-Benzoxazin-4-ones, 4-3,1-Benzothiazin-4-ones, and 4-3,1-Benzothiazine-4-thiones
pp. 1
Intramolecular Cyclization of [(2-Aminophenyl)amino]acetonitrile
pp. 1
By Heterofunctional Groups
pp. 1
Cyclocondensation of Arylhydrazones with Malononitrile
pp. 1
Substitution of Existing Substituents
pp. 1
Condensation of 5,7-Dihydrofuro[3,4-]pyridines with Hydrazines
pp. 1
Synthesis by Ring Transformation
pp. 1
Halogenation
pp. 1
Synthesis by Other Methods
pp. 1
From Quinolines
pp. 1
Synthesis by Ring Transformation
pp. 1
Reaction of 1,2-Dicarbonyl Monohydrazones with Methylene-Activated Compounds
pp. 1
Of Oxygen and Sulfur Functionalities
pp. 1
Chlorination
pp. 1
From Arene-1,2-dithiols and Substituted Acetyl Halides
pp. 1
Using Iodomethane
pp. 1
Fragments C—C—C—C and N—N
pp. 1
Fragment C—C—C—C and Two S Fragments
pp. 1
Synthesis by Substituent Modification
pp. 1
By Formation of Three N—C Bonds
pp. 1
From 2-(Azidomethyl)benzenediazonium Tetrafluoroborate and Nitriles
pp. 1
Fragments N—Arene—N and Arene
pp. 1
Cyclization of Aminohetarenes Containing a 2-Nitrophenyl Substituent
pp. 1
By Arylsulfanyl Migration
pp. 1
Synthesis of Adenine
pp. 1
Cleavage of Tetrazolopyridazines with Phosphines (The Staudinger Reaction)
pp. 1
Cyanation and Carbonylation
pp. 1
By Introduction of Substituents (Exchange of Hydrogen)
pp. 1
Fragments C—C, C—C and Two S Fragments
pp. 1
Reaction Promoted by Copper(I) Chloride
pp. 1
From Selenium and an Organometallic Compound
pp. 1
By Substitution of Hydrogen
pp. 1
From 2-(Acylamino)benzaldehydes or 2-(Acylamino)phenyl Ketones and Ammonia (Bischler's Synthesis)
pp. 1
Fragments N—Arene—C and N—C
pp. 1
By Ring Enlargement
pp. 1
Of Halogens
pp. 1
O-Methylation and O-Demethylation
pp. 1
Intramolecular Cyclization of 2-(Acylamino)nicotinamides or 2-(Acylamino)nicotinonitriles
pp. 1
Fragments N—Arene and N—C—C
pp. 1
Condensation of Pyridine-2,3-diamines with a Two Carbon Atom Donor
pp. 1
By Substitution of Chlorine
pp. 1
Reaction of Alkyl 3-(Carbamoyldiazenyl)but-2-enoates with Alkyl 2-Acetylacetoacetates and Similar Compounds
pp. 1
From Isoindole Derivatives
pp. 1
Cyclization of Diazotized 2-Alkynylanilines (The Richter Synthesis)
pp. 1
Substitution with Nitrogen Functionalities
pp. 1
From a 1,2-Bifunctional Compound and Ammonia or Ammonium
pp. 1
Synthesis by Substituent Modification
pp. 1
Fragments S—C—C and S—C—C
pp. 1
N-Alkylation of Pteridinones or Their Derivatives
pp. 1
By N-Dealkylation
pp. 1
Fragments O—C—C and O—C—C
pp. 1
Cyclization with Sulfocinnamic Acid
pp. 1
Aromatization of a Diphosphonium Salt
pp. 1
Modification of Substituents
pp. 1
Of the Carbocyclic Ring
pp. 1
Use of Diketones
pp. 1
From 2,4,5,6-Tetrasubstituted Pyrimidines
pp. 1
N-Alkylation
pp. 1
Dibenzo[,][1,4]dioxins by Base-Induced Coupling of Benzene-1,2-diols with Activated Fluorobenzenes
pp. 1
From Alkane-1,2-diamines
pp. 1
Cyclization via Ring-Closing Metathesis of Alkenes
pp. 1
Cyclocondensation of 3-Hydrazonopyridines with Aldehydes
pp. 1
S-Alkylation
pp. 1
Nitro Group Modification
pp. 1
From Alkene-1,2-diamines
pp. 1
Fragments N—C—C, C—C, and N
pp. 1
The Hofmann Rearrangement
pp. 1
By Formation of Four Se—C Bonds
pp. 1
From Indole Derivatives
pp. 1
From Sulfanylpurines
pp. 1
Aromatization
pp. 1
Formation of Metal Complexes with 1,4-Diselenins
pp. 1
Cyclization of Dichlorides by Tandem Michael–Nucleophilic Substitution Processes
pp. 1
Reductive Cyclization of (6-Aminopyrazin-2-yl)malonitriles
pp. 1
Radical Substitution Reactions
pp. 1
Substitution of Halogens by Azide
pp. 1
By Free-Radical Reaction Catalyzed by Iron(II) Ions
pp. 1
With Dienophiles Containing a C≡C Bond
pp. 1
Homolytic Alkoxycarbonylation and Amidation
pp. 1
Transformation of a 1,3-Diselenol-1-ium Salt
pp. 1
Modification of Substituents
pp. 1
From -Arylcarbodiimides or -Arylketenimines and Ethyl Aminocarbonylcarbamate or N,N-Disubstituted Cyanamides
pp. 1
1,4-Benzodioxins by Elimination of Bromine or Hydrogen Bromide from 2,3-Dibromo-2,3-dihydro-1,4-benzodioxins
pp. 1
Reaction with Guanidines
pp. 1
Amino Group Transformations
pp. 1
Thermolytic or Photolytic Synthesis of Polycyclic 1,2-Diselenins from Diaryl Selenides
pp. 1
From Benzene-1,2-diamines and α-Oxo Imino Compounds
pp. 1
Modification of Hydroxyalkyl and Similar Substituents
pp. 1
From Oxazinones or Thiazinones
pp. 1
By Formation of One C—C Bond
pp. 1
From Zinc Selenolates
pp. 1
From 4-Methyl-6-thioxo-1,6-dihydropyrimidine-5-carbonitriles and 2-Ylidenemalononitriles
pp. 1
From Sulfanyl- and (Alkylsulfanyl)purines
pp. 1
Pyrido[3,4-]pyridazines
pp. 1
Reaction with Nitriles
pp. 1
Oxidative Cleavage of Benzo-1,2-diazines
pp. 1
Alkylation, Arylation, and Related Reactions
pp. 1
From 2-Aminobenzamides and Carboxylic Acids, Esters, Ortho Esters, or Carboxamides
pp. 1
Oxidation of 1,4-Dithianes
pp. 1
Synthesis by Ring-Closure Reactions
pp. 1
From 1,2-Benzodithiole Sulfoxide
pp. 1
With Potassium Hexacyanoferrate(III)
pp. 1
Modification of Substituents
pp. 1
Methyl Group Modification
pp. 1
Oxidative Cyclization of Unsaturated 1,4-Dioximes into Pyridazine 1,2-Dioxides
pp. 1
Vilsmeier Reaction of 2-Phenyl-1,4-benzodioxin
pp. 1
Synthesis from a Pyrimidooxadiazinetrione
pp. 1
Pyrido[4,3-]pyridazines
pp. 1
From Preformed Purine Salts
pp. 1
By Halogenation
pp. 1
Palladium-Catalyzed Intramolecular Arylation of 4-(2-Bromobenzylamino)pyrimidines
pp. 1
Fragment C—C—C—C and Two Se Fragments
pp. 1
From 2-Methyl-4-pyrido[4,3-][1,3]oxazin-4-one
pp. 1
From -Arylnitrilium Salts, -Arylimidoyl Chlorides, or -Arylimidates and Nitriles (Meerwein's Quinazoline Synthesis)
pp. 1
Fragments N—C—N, C—C, and C
pp. 1
From Benzopentathiepins and Arenes
pp. 1
Coupling with Alkynes
pp. 1
Reaction of 2-(Alkoxycarbonyl)quinones with Methylglyoxal 1-Methylhydrazone
pp. 1
From 1,6-Naphthyridines
pp. 1
Aromatization
pp. 1
Other Cross-Coupling Reactions for Arylation
pp. 1
Introduction of a Nitrogen Functionality
pp. 1
From Phthalazines
pp. 1
From Benzene-1,2-diamines and 3-Arylisoxazol-5(4)-ones
pp. 1
By Formation of One N—C and One C—C Bond
pp. 1
Deoxygenation of Phenazine 5,10-Dioxide by Catalytic Reductions
pp. 1
Pyrazines from Quinoxalines and Phenazines
pp. 1
By Formation of Two O—C Bonds
pp. 1
Addition of an Aryl Group
pp. 1
Reaction with Enzymes
pp. 1
Fragments Arene—N—C—C and N
pp. 1
Deamination by Adenosine Deaminase
pp. 1
Reaction of 3,3-Diheterosubstituted Acrylates with Amidine Derivatives
pp. 1
3-Alkoxy- and 3,3-Dialkoxyacrylonitriles
pp. 1
Oxidation of 1,4-Diphenyl-1,4-dihydro-2,3-benzodithiin
pp. 1
From 2-Amino--arylbenzenecarboximidamides and Formic Acid
pp. 1
N-Oxidation
pp. 1
Reaction of 3,3-Bis(methylsulfanyl)acrylonitrile with Amides
pp. 1
By Radical Photochemical Reactions
pp. 1
With Dienophiles Containing a C=C Bond
pp. 1
From 4,5-Disulfanyl-3-1,2-dithiole-3-thione
pp. 1
By Nitration
pp. 1
With Unsymmetrical 1,2-Dicarbonyl Systems
pp. 1
From N′-Substituted -Arylimidamides or -Arylisothioureas
pp. 1
From Anthranilic Acid Derivatives and Nitriles
pp. 1
Substitution of Existing Substituents
pp. 1
Substitution of Existing Substituents
pp. 1
Reaction of 3,3-Diaminoprop-2-en-1-one Derivatives with Amidine Derivatives
pp. 1
Metalation
pp. 1
Fragments C—Hetarene—C and C—C
pp. 1
Syntheses from 5-Nitrosopyrimidin-4-amines
pp. 1
Condensation of 1,2-Diketones with Cyanoacetic Acid Derivatives and Hydrazine
pp. 1
Telluranthrene from Tellurium and an Organomercury Compound
pp. 1
Synthesis of Hypoxanthine
pp. 1
Rearrangement of Substituents
pp. 1
Pyrido[3,2-]pyridazines
pp. 1
Synthesis of a 1,2-Diphosphininium Derivative
pp. 1
By Formation of One N—C and One C—C Bond
pp. 1
Reduction
pp. 1
By Formation of Two C—C Bonds
pp. 1
From 1-Ethyl-1,2-diphenyldisulfan-1-ium
pp. 1
From Benzene-1,2-diamines and 2,2-Bis(trifluoromethyl)oxazol-5(2)-ones
pp. 1
Suzuki Cross Coupling of Chloro(methoxy)pyridazin-3(2)-ones
pp. 1
Fragments S—C—C and S—C—C
pp. 1
Oxidation of Theophylline Derivatives with Lead(IV) Acetate
pp. 1
From Other Pyrido[2,3-]pyrimidines
pp. 1
Fragments Arene—C and N—N—C
pp. 1
From Other Disubstituted Pyrimidines
pp. 1
Desulfurization
pp. 1
Dibenzo[,][1,4]dioxins from the Diels–Alder Reactions of 1,4-Benzodioxin and Benzo[]furo[3,4-][1,4]dioxins
pp. 1
Hofmann or Curtius Rearrangement
pp. 1
Fragments N—C, N—C, and Two C Fragments
pp. 1
Condensation of 5-Acylpyridazin-4-amines with Acetals
pp. 1
Of Pyrimido[4,5-][1,2]diazepines
pp. 1
Stille Coupling of 2-(Trimethylstannyl)-1,4-benzodioxin with a Bromoalkene
pp. 1
Chlorination with the Vilsmeier Reagent
pp. 1
Acylation
pp. 1
Alkynylation and Related Reactions
pp. 1
2-Acylquinoxalines by Oxidative Ring Contraction of 2,4-Disubstituted 1,5-Benzodiazepines
pp. 1
Cyclization of 1-Aroyl-2-benzylidenehydrazines
pp. 1
Dimerization via Diels–Alder Reaction of Thioaldehydes
pp. 1
N-Acylation
pp. 1
O-Alkylation and O-Dealkylation
pp. 1
Iron(II)-Catalyzed C-Alkylation
pp. 1
By Hydrogen
pp. 1
Cycloamination of (4-Halopyrimidin-5-yl)propanoates
pp. 1
Phenazin-1-ol 10-Oxides and 5,10-Dioxides from Benzofurazan 1-Oxides and Cyclohexane-1,2-dione
pp. 1
Synthesis from 5-Diazenylpyrimidin-4-amines
pp. 1
From Halopurines
pp. 1
From Substituted Pyrimidines
pp. 1
Condensation of 4-(Iminomethyl)pyridazines with Enolates
pp. 1
From Benzofurazan 1-Oxide and Benzene-1,4-diol Derivatives Catalyzed by Molecular Sieves
pp. 1
Substitution of Sulfur by Carbofunctional Groups
pp. 1
By Annulation to the Pyrazine Ring
pp. 1
Cyclization of 2-Aminoindophenols
pp. 1
By Formation of One C—C Bond
pp. 1
Fragments Se—C—C—C and C—Se
pp. 1
By Michael Addition
pp. 1
Of Quinolinimides via Rearrangement or Ring Opening and Cyclization
pp. 1
Synthesis of 3-Aroylcinnolines from Aryl Methyl Ketones
pp. 1
Addition of Carbon Functionalities
pp. 1
Oxidative Dehydrazination of Hydrazinophthalazines
pp. 1
Fragment N—Arene—C—C—N
pp. 1
Intramolecular [4 + 2] Cycloaddition of 3-(Alkynylamino)-1,2,4,5-tetrazines
pp. 1
From 1,2,3,4-Tetrafluoro-5,6-diiodobenzene and Tellurium
pp. 1
From 4,5-Disubstituted Pyrimidines
pp. 1
N-Alkylation and N-Arylation
pp. 1
From 2-3,2,1-Benzoxathiazine-2,4(1)-dione
pp. 1
From 4(5)-Aminoimidazole-5(4)-carboxamides
pp. 1
From 4-Pyrido[3,4-][1,3]oxazin-4-ones
pp. 1
From β,β′-Difunctional Secondary Amines (or Amides) and Ammonia
pp. 1
Fragments Se—C—C—Se and C—C
pp. 1
By Formation of One S—S and One C—C Bond
pp. 1
Pyrido[3,4-]pyrimidines
pp. 1
Sulfanylation
pp. 1
Oxidation of the Selenium Atoms in Selenanthrene
pp. 1
By Reduction with Sodium Nitrite
pp. 1
From 1,2-Dicarbonyl Compounds
pp. 1
Of Heteroatoms
pp. 1
Reaction of Vinamidinium Salts with Amidine Derivatives
pp. 1
Of Hydroxyalkyl and Similar Substituents
pp. 1
From a 1,2-Dihalobenzene
pp. 1
By Formation of Two C—C Bonds
pp. 1
Intramolecular Reductive Cyclization of --(4-Bromo-2-nitrophenyl)alanine
pp. 1
Oxidation of Benzene-1,2-diamine
pp. 1
Alkylation of 1,4-Benzodioxin-6,7-dicarbaldehyde
pp. 1
From Hydroxypurines
pp. 1
By Halogenation
pp. 1
Intramolecular Cyclization of Ethyl 2-[(Anilinocarbonyl)amino]nicotinates or 2-[(Anilinocarbonothioyl)amino]nicotinates
pp. 1
Fragment C—N—N—C—Arene
pp. 1
From Benzene-1,2-diamines and α-Oxoaldehydes
pp. 1
Hofmann or Curtius Rearrangement
pp. 1
Cyclization of 6-(Acylamino)pyrimidines with a One-Carbon Synthon
pp. 1
By Addition of Grignard Reagents
pp. 1
From 4-Aminopyrimidine-5-carbonitrile
pp. 1
With Terminal Alkynes
pp. 1
From 2-Fluorobenzaldehydes and Amidines
pp. 1
From 2-Fluorophenyl Ketones and Guanidine
pp. 1
Halogenation
pp. 1
Synthesis of 3-Arylcinnoline-4-carbonitriles by Reaction of Acetophenone Methyl(phenyl)hydrazones and Tetracyanoethene
pp. 1
Of Carbon Functionalities
pp. 1
Cyclization of 1-(Cyanoacetyl)-2-methylisoureas
pp. 1
From 1,2-Dilithiohetarenes and Sulfur(II) Compounds
pp. 1
Rearrangement of Substituents
pp. 1
By the Fusion Reaction
pp. 1
By Formation of One N—C and One C—C Bond
pp. 1
N-Oxidation
pp. 1
From 2,3-Dichloronaphthoquinone and Sodium Selenide
pp. 1
From Alkene-1,2-diamines
pp. 1
Friedel–Crafts Acylation of Dibenzo[,][1,4]dioxins
pp. 1
Condensation of 5-Formyl- or 5-Carboxypyrimidin-4-amines with Malonates
pp. 1
By Photochemical Reaction
pp. 1
Oxidation of Hydro Precursors
pp. 1
Nitration
pp. 1
Synthesis by Ring-Closure Reactions
pp. 1
Alkylation
pp. 1
Insertion of Hydrazine into ()-3-Benzylidenefuro[3,4-]pyridin-1(3)-ones
pp. 1
Substitution by Alkoxy or Siloxy Groups
pp. 1
Condensation of Hydrazine with 1-Pyrrolo[3,4-]pyridine-1,3(2)-dione
pp. 1
Dehydrative Cyclization of 2-Acetamidonicotinamides
pp. 1
Synthesis by Photolysis of Unsaturated 18-Membered Thia-Crown Ethers
pp. 1
Stille Cross-Coupling Reaction and Related Reactions
pp. 1
By Formation of One N—C Bond
pp. 1
Synthesis from 1,8-Diketones
pp. 1
Condensation of Appropriately Modified Pyrimidine-5-carbaldehydes with Amines
pp. 1
Halopurines
pp. 1
Fragments N—C—N—C and Arene
pp. 1
From -(α-Alkoxyalkyl)benzotriazoles and Nitriles
pp. 1
By Direct Synthesis
pp. 1
Reaction of Alkynes with Nitriles
pp. 1
Fragment N—C—Arene—N—C
pp. 1
Reaction of 3,3-Bis(methylsulfanyl)acrylates with Amidine Derivatives
pp. 1
Of Carbon Functionalities
pp. 1
From an α-Amino Ketone, an α-Hydroxy Ketone, and Ammonium Acetate
pp. 1
By Formation of Two N—C Bonds and One C—C Bond
pp. 1
Pyrimidopyrimidines
pp. 1
Fragments N—C—C, N—C, and C
pp. 1
N-Arylation
pp. 1
Of Nitro Groups
pp. 1
Introduction of Aryl Groups
pp. 1
Manganese(IV) Oxide Promoted Oxidative Dimerization
pp. 1
Synthesis by Ring Transformation
pp. 1
With 1,2-Diaza-1,3-dienes
pp. 1
By Reductive Cleavage of Nitrogen
pp. 1
Nitration of Phenazine 5-Oxides
pp. 1
With Ammonium Hydroxide
pp. 1
Dehydrogenation of 1,2,3,4-Tetrahydrophenazines
pp. 1
Of 1,4-Benzodiazepines
pp. 1
Of Heteroatoms
pp. 1
From Benzene-1,2-diamines and Benzo-1,2-quinones
pp. 1
By Substitution of Hydroxy Groups
pp. 1
Fragments C—S—C and C—S—C
pp. 1
Condensation and Reduction of 2-Amino-2′-nitrobiaryls
pp. 1
Addition Reactions
pp. 1
Oxidation with Antimony(V) Fluoride
pp. 1
Aromatization Using 2,3-Dichloro-5,6-dicyanobenzo-1,4-quinone
pp. 1
Intramolecular Cyclization of 3-(Acylamidino)pyridin-2-amines
pp. 1
Fragments N—C—Arene and N—C
pp. 1
Pyridazinopyridazines
pp. 1
Substitution of Heteroatoms
pp. 1
N-Alkylation of Pteridinones or Their Derivatives
pp. 1
By Nucleophilic Displacement of Nitrile Groups
pp. 1
Fragments C—N—C—Arene and N
pp. 1
Pyrido[2,3-]pyrimidines
pp. 1
From Saturated 4-Oxo Acids and Derivatives, with Subsequent Oxidation
pp. 1
Fragments N—Arene and N—Arene
pp. 1
From Diphenyl Selenide with Potassium Amide
pp. 1
Cyclization of Piperidones with a N—C—N—C Donor
pp. 1
From 1,2-Diazepines
pp. 1
From 5-Amino-2,6-dihydroxypyrimidine-4-carboxylic Acid
pp. 1
Synthesis of Onium Salts
pp. 1
Of Metals
pp. 1
From 1,7-Naphthyridines
pp. 1
Of Amino Groups
pp. 1
From 1,2-Dimethoxybenzene and a Selenium Reagent
pp. 1
Fragments Hetarene and C—C—C—C
pp. 1
Fragments N—Arene—N—C and C
pp. 1
Reaction of Diphenylmethanethione with Tetracyanoethene
pp. 1
Of Metals
pp. 1
Cyclization of 3-Nitrogen-Functionalized Pyridine-4-carboxylic Acids with Nitrogen-Containing Compounds
pp. 1
Replacement of Hydrogen by Deuterium
pp. 1
By Formation of Two N—C Bonds
pp. 1
From Ammonium Salts
pp. 1
Reaction of Malononitriles with Amidine Derivatives
pp. 1
Reaction of 4,4-Bis(methylsulfanyl)-1,3-diazabuta-1,3-diene
pp. 1
Intramolecular Diazo Coupling of 4-Hetarylpyridin-3-amines
pp. 1
By Formation of Two N—C Bonds and One C—C Bond
pp. 1
Of Metals
pp. 1
By Formation of One N—C and One C—C Bond
pp. 1
From Seven-Membered Rings Containing an Additional Heteroatom
pp. 1
From -Arylguanidines, -Arylbenzimidamides, or -Arylisothioureas and Aryl Isothiocyanates, 4-Tosylcarbonimidic Dichloride, Phosgene, Alkyl Chloroformates, or Carbon Monoxide
pp. 1
From [1,2,5]Oxadiazolo- and [1,2,5]Thiadiazolo[3,4-]pyrazines
pp. 1
By Formation of Three N—C Bonds and One C—C Bond
pp. 1
By Formation of One N—C and Two C—C Bonds
pp. 1
From Substituted Pyridazines
pp. 1
By Carbofunctional Groups
pp. 1
Reaction of β-Oxo Esters with Amidine Derivatives
pp. 1
From Methyl 6-Methyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
pp. 1
By Reduction with Sodium Borohydride
pp. 1
From Benzene-1,2-diamines and Ethyl Ethoxy(imino)acetate
pp. 1
Modification of Substituents
pp. 1
Substitution of Existing Substituents
pp. 1
Using Amines
pp. 1
Fragments N—Arene and C—N—C
pp. 1
Cobalt(II)-Mediated Dimerization of α,β-Unsaturated Thioacylsilanes
pp. 1
Coupling with Alkenes
pp. 1
By Exchange of Chlorine for Iodine
pp. 1
Dimerization of -Cyanothioacetimidate
pp. 1
Formal Exchange of Ring Members with Retention of the Ring Size
pp. 1
Intermolecular [4 + 2] Cyclization of 1,2,4,5-Tetrazines
pp. 1
Addition of an Alkyl Group
pp. 1
By Formation of Four Te—C Bonds
pp. 1
From Pentachlorophenyllithium and Aryl Nitriles
pp. 1
Reaction of 3,3-Disulfanylprop-2-en-1-ones with Amidine Derivatives
pp. 1
Fragment N—C—C—N and Two C Fragments
pp. 1
Replacement of Magnesium Halide in Pyridazinyl Grignard Compounds
pp. 1
By C-Alkylation
pp. 1
From a Bisfulvene Tetraester
pp. 1
Synthesis by Ring Transformation
pp. 1
Rearrangement of Substituents
pp. 1
From -(1,3-Oxazol-5-yl)ureas
pp. 1
Synthesis from Pyrimidine-4,5-diamines and Diketones
pp. 1
Synthesis of 1,4-Diphenyl-1,4-dihydro-2,3-benzodithiin
pp. 1
O-Sulfonylation
pp. 1
From 2,6-Disubstituted 4-Aminopyrimidine-5-carboxamides
pp. 1
Synthesis by Substituent Modification
pp. 1
Addition Reactions to Purine Double Bonds
pp. 1
Ring Opening of Bicyclic Pyridazines
pp. 1
From Alkane-1,2-diamines
pp. 1
Degradation of Condensed Pyrazines
pp. 1
Reaction of 3-Arylacrylonitriles with Amidine Derivatives
pp. 1
N-Alkylation of Pteridinamines
pp. 1
Reaction with Diazo Compounds
pp. 1
Reaction with Benzimidate
pp. 1
Fragments N—C—C and N—C—C
pp. 1
Substitution of Existing Substituents
pp. 1
Ring Closure with Sulfur Monochloride
pp. 1
Elimination Reactions
pp. 1
Pyrido[2,3-]pyrimidines
pp. 1
By Formation of One C—C Bond
pp. 1
Deoxidative Cyanation of Pyrazine -Oxides
pp. 1
Cycloamination of 5-Ethynylpyrimidine-4-carboxylates
pp. 1
Oxidative Cyclization with Iron(III) Chloride/Ethanol
pp. 1
Condensation of Hydrazine with 2-Formylquinoline-3-carboxylate
pp. 1
2-Nitrophenazine 10-Oxide by Photochemical Reaction of 2,4-Dinitrodiphenylacetamide
pp. 1
Of Hydroxy, Alkoxy, and Aryloxy Groups
pp. 1
Fragments C—C—Se—C—C and Se
pp. 1
Ring Contraction Promoted by Photolysis
pp. 1
Reaction of Methylene-Activated Acid Hydrazides with 1,2-Dicarbonyl Compounds
pp. 1
Intramolecular Cyclization of 3-Pyridylhydrazones
pp. 1
Condensation of 1,2,3,6-Tetrahydropyridin-4-amines with Semicarbazones
pp. 1
From Alkoxypurines or (Trimethylsiloxy)purines
pp. 1
Synthesis of Onium Salts
pp. 1
Solid-Phase Synthesis from a Polymer-Bound Benzene-1,2-diamine and α-Bromo Ketones
pp. 1
From Substituted Pyrimidines
pp. 1
Reaction with Urea
pp. 1
From Alkoxypurines
pp. 1
By Formation of Four S—C Bonds
pp. 1
Fragments C—N—C—C—C and N
pp. 1
Aromatization
pp. 1
Cyclization of Hydrazones Derived from Diazotized 2-Formyl- or 2-Acetylanilines
pp. 1
By Hydrogen
pp. 1
Nitration
pp. 1
From 6-Methylpyrimidine-5-carboxylates and Alkynes or Alkenes
pp. 1
Reaction of Ketones
pp. 1
Intramolecular Cyclization of 4-Nitro--prop-2-ynylbenzene-1,2-diamine
pp. 1
Reductive Dehalogenation of Halocinnolines
pp. 1
By Formation of Two N—C and Two C—C Bonds
pp. 1
Incorporating a (2-Formylpyridin-3-yl)copper Reagent in Pyrido[2,3-]pyridazine Synthesis
pp. 1
From 3-Chloropyrazine-2-carboxylates and Guanidine or Synthetic Equivalents
pp. 1
Removal of Heterofunctional Groups
pp. 1
Fragments Arene—C and N—C—N
pp. 1
From α-Amino Oximes
pp. 1
Cyclization of Diethyl [(Pyrazin-2-ylamino)methylene]malonates and Related Compounds
pp. 1
Reaction of Malonimidamides with Esters
pp. 1
By Cycloaddition Reactions
pp. 1
From 1-Acyl-3-phenylureas
pp. 1
From 5-Nitrosopyrimidin-4-amines
pp. 1
Condensation of Hydrazine with Pyrrolo[3,4-]pyridinone
pp. 1
Reduction
pp. 1
Fragment C—C—S—S—C—C
pp. 1
Introduction of Alkynyl Groups
pp. 1
Synthesis by Substituent Modification
pp. 1
Addition of Heteroatoms
pp. 1
Dehydrogenation of Dihydropyrazines
pp. 1
Modification of Amine Substituents
pp. 1
Modification of Carbon Substituents
pp. 1
Oxidation of the Dithiin Ring
pp. 1
Condensation of 1,4-Dicarbonyl Compounds with Hydrazine
pp. 1
Reaction of 3-Alkoxyacrylates with Amidine Derivatives or Cyanamide
pp. 1
Fragments S—C—C and S—C—C
pp. 1
Addition Reactions
pp. 1
From Cyanogen
pp. 1
From 4,5-Disubstituted Pyrimidines
pp. 1
By Formation of One S—S Bond
pp. 1
From 2-Aminobenzamides and Other One-Carbon-Unit Transfer Reagents
pp. 1
Of Ketones, Aldehydes, and Derivatives
pp. 1
Rearrangement of Substituents
pp. 1
Reaction of 4,4-Dimethoxybutan-2-one
pp. 1
By the Metal Salt Procedure
pp. 1
By Nitration
pp. 1
By Metal–Halogen Exchange
pp. 1
By Formation of One N—C and One C—C Bond
pp. 1
Alkoxypurines
pp. 1
Fragment N—C—N—Arene—C
pp. 1
From 2-3,1-Benzoxazine-2,4(1)-diones (Isatoic Anhydrides)
pp. 1
N-Oxidation
pp. 1
Cycloaddition Reactions
pp. 1
Cyclization of Phenylhydrazones
pp. 1
Electrocyclization of 5-(Methyleneamino)-6-vinylpyrimidines
pp. 1
From Pyranopyrimidines
pp. 1
By Ring Enlargement
pp. 1
With Symmetrical 1,2-Dicarbonyl Systems
pp. 1
By Condensation of Two Different α-Amino Ketones or Cyanides
pp. 1
Substitution of an Oxygen Functionality
pp. 1
From α-Amino Nitriles
pp. 1
By Deuteration and Tritiation
pp. 1
From 2,3-Disubstituted Pyrazines and One-Carbon Units
pp. 1
Alkylation, Arylation, and Alkenylation of Pyrazine -Oxides
pp. 1
Intramolecular Cyclization of 5-(Methyleneamino)pyrimidines
pp. 1
Removal of Carbofunctional Groups from Hydro Precursors
pp. 1
Functionalized Methylation
pp. 1
Diazotization/Replacement
pp. 1
Modification of Ketones, Aldehydes, and Derivatives
pp. 1
Homolytic Acylation and Amidation
pp. 1
1,4-Benzodioxins by Isomerization of Exocyclic Alkenes
pp. 1
From 2,3-Disubstituted Pyrazines
pp. 1
Fragments S—C, S—C, and C—C
pp. 1
Fragments N—N, C—C, and C—C
pp. 1
Addition Reactions
pp. 1
Hetero-Diels–Alder Reactions of 2-Vinylpyridines
pp. 1
Of Hydrogen
pp. 1
1,4-Benzodioxins by Condensation of Benzene-1,2-diols with an Unsaturated Dielectrophile
pp. 1
By Traube Reaction of Pyrimidine-4,5-diamine with Glyoxal
pp. 1
Condensation of 5-Carbo-Functionalized Pyrimidines with Enamines, Acetamides, or Acetonitriles
pp. 1
2-Substituted 1,4-Benzodioxins from 2-Lithio-1,4-benzodioxins
pp. 1
Fragment Se—C—C—C—C—Se
pp. 1
Of 4,1,5-Benzoxadiazocines
pp. 1
Fragments C—N—C, C—C, and N
pp. 1
Synthesis of a 1λ,4λ-Diphosphinine by a [4+2]-Cyclization Reaction
pp. 1
Rearrangement of Substituents
pp. 1
By Formation of Four S—C Bonds
pp. 1
Condensation of 5,6-Dicarbonyl-Functionalized Pyridinones with Hydrazine
pp. 1
Replacement of Stannyl or Silyl Groups by Carbon Substituents
pp. 1
By Ring Contraction
pp. 1
Fragments C—C, C—C, and Two N Fragments
pp. 1
3-(2-Hydroxyaryl)quinoxaline 1-Oxides from Benzofuroxan and Benzo[]furan-3(2)-ones
pp. 1
Cyclocondensation of Pyridazine-3-carbohydrazides with Aldehydes
pp. 1
From 2-Aminobenzonitriles and Chlorosulfonyl Isocyanate, Urea, or Thiourea
pp. 1
Direct Introduction of Substituents by Electrophilic Reactions
pp. 1
Fragment C—N—C—C—N—C
pp. 1
Of Hydrogen
pp. 1
By Photolysis of 1,2,5,6-Tetrathiocins
pp. 1
Of Hydrogen
pp. 1
Reduction of Quinazoline -Oxides
pp. 1
By Formation of One N—C Bond
pp. 1
By Direct Amination
pp. 1
Intramolecular Cyclization of Suitably Modified Diazo Compounds, Hydrazones, Azides, and Hydrazides
pp. 1
Sulfonation and Chlorosulfonation
pp. 1
From 2-Hydroxybenzoyl or 2-Chlorobenzoyl Chlorides and Carboxamides
pp. 1
From Purine Nucleosides
pp. 1
Oxidation of 1,2-Dihydroquinoxaline Derivatives
pp. 1
By Decarboxylation
pp. 1
From 4,5,6-Trisubstituted Pyrimidines
pp. 1
By Formation of One S—S and Two S—C Bonds
pp. 1
From (Methylsulfanyl)- and Mesylpurines
pp. 1
From Pyrimidine-4,5-diamines (Traube Synthesis)
pp. 1
From Furan Derivatives
pp. 1
By Annulation to an Arene
pp. 1
By Rearrangement of 1,2,4-Triazines
pp. 1
Decarboxylation
pp. 1
Alkenylation and Related Reactions
pp. 1
Dehalogenation
pp. 1
Cyclization of 3-Aminopyridine-4-carboxylates with a N—C Unit
pp. 1
N-Oxidation
pp. 1
Fragment N—Arene—N—Arene
pp. 1
1,4-Diphosphinines
pp. 1
With Halogen-Substituted 1,2-Diaza-1,3-dienes
pp. 1
Fragments N—C—C and N—C—C
pp. 1
Cyclization with Dimethyl Diselenide
pp. 1
Oxidative Coupling of 2-Chloroetheneselenol Derivatives
pp. 1
By Formation of One N—C Bond
pp. 1
Synthesis of 7-Substituted Purines
pp. 1
Electrophilic Substitution Reactions
pp. 1
Enzymatic Oxidation
pp. 1
Intramolecular Cyclization of a N—C—C—N—C—C Fragment
pp. 1
Intramolecular Cyclization of a N—C—C—N—C—C Fragment
pp. 1
Pyrido[3,2-]pyrimidines
pp. 1
1-Monosubstituted and 1,9-Disubstituted Dibenzo[,][1,4]dioxins from 1-Lithio- or 1,9-Dilithiodibenzo[,][1,4]dioxin
pp. 1
N-Acylation
pp. 1
Synthesis of 1,2-Diselenins from 1,4-Bis(benzylselanyl)buta-1,3-dienes by Debenzylation
pp. 1
From 2,4-Diaryl-4-(2-nitrophenyl)oxazol-5(4)-ones
pp. 1
Synthesis by Ring-Closure Reactions
pp. 1
Substitution of Halogen
pp. 1
Intermolecular Cyclizations of Malononitrile Dimer and Hydrazones, or Acetonitriles and Pyridazinediones
pp. 1
Carboxylation and Cyanation
pp. 1
Of Sulfur-Containing Groups
pp. 1
Of Metals
pp. 1
By Elimination
pp. 1
From Benzyne and Elemental Selenium
pp. 1
Introduction of Hetero Substituents
pp. 1
Elimination Reactions
pp. 1
Polyhalogenated Dibenzo[,][1,4]dioxins by Direct Halogenation of Dibenzo[,][1,4]dioxins with Chlorine or Bromine
pp. 1
Intramolecular Cyclization of [(Pyrimidin-5-yl)methylene]malononitriles
pp. 1
Vicarious Nucleophilic Substitution
pp. 1
Fragment N—Arene—C—N—C
pp. 1
Synthesis of Phenazine 5,10-Dioxides
pp. 1
Introduction of Oxygen Substituents
pp. 1
By Nucleobase Anion Glycosylation
pp. 1
Direct Cyanation of Electron-Deficient Pyridazinones
pp. 1
With O-Nucleophiles
pp. 1
Introduction of Alkyl and Other Groups
pp. 1
Cycloamination of Pyridine-3,4-dicarboxylates with Hydrazines
pp. 1
Modification of Amino Groups
pp. 1
Intramolecular Cyclization of 6-(3-Oxoalkyl)pyrimidin-5-amines
pp. 1
Cyclization of Arylidenemalononitriles or Enamines with Isothiocyanates or Isocyanates
pp. 1
Deoxygenation of -Oxides
pp. 1
Amination
pp. 1
Cyclization of Hydrazones of 4-Oxoalkenoic Acid Derivatives
pp. 1
Fragment C—C—N—N—C—C
pp. 1
From Four Equivalents of a Nitrile
pp. 1
With Sulfur Monochloride
pp. 1
Substitution of Heteroatoms
pp. 1
Synthesis by Ring Transformation
pp. 1
Synthesis with Active Methylene Compounds
pp. 1
Cyclization of -(2-Nitrobenzylidene)benzene-1,2-diamine with Potassium Cyanide
pp. 1
Rearrangement of Substituents
pp. 1
By Ring Enlargement
pp. 1
Formation of 2,3-Diphenyl-1,4-dithiin
pp. 1
Synthesis by Ring Transformation
pp. 1
Reaction of 3-Aminoacrylates
pp. 1
Rearrangement Promoted by Photolysis
pp. 1
Synthesis by Ring Expansion of Purine Derivatives
pp. 1
Reaction of 1,3-Diketones
pp. 1
Cycloamination of 2-Halonicotinamides
pp. 1
Electrochemical Reduction of Benzo-1,2-quinone Dioxime
pp. 1
From Benzene-1,2-diamine and 1,4-Dioxane-2,3-diol
pp. 1
Reductive Dehalogenation of Halopyridazines
pp. 1
From Benzene-1,2-diamines and Aryl(arylimino)acetonitriles
pp. 1
Cycloamination of 4-Vinylpyridazine-3-carboxylates
pp. 1
Oxidation of Dihydrocinnolines
pp. 1
Cyclization with Aldehydes
pp. 1
Cyclization of 3-(Cyanoamino)acrylonitriles
pp. 1
Reaction with Active Methylene Compounds
pp. 1
Telluranthrene from Diaryl Telluride and Tellurium
pp. 1
Cyclization of Dibromides Promoted by Phase-Transfer Catalysts
pp. 1
Reaction of Sodium 3,3-Dimethoxy-2-(methoxycarbonyl)prop-1-en-1-olate with Amidines
pp. 1
Substitution of Halogens: Alkylation
pp. 1
Cyclization of 3-Aminopyridazine-4-carbonitrile with Malonates
pp. 1
Intermolecular [4 + 2] Cycloaddition of 1,2,4,5-Tetrazines
pp. 1
-Bromosuccinimide-Induced Ring Formation
pp. 1
From Pyrans or Pyrylium Salts
pp. 1
Suzuki–Miyaura Cross-Coupling Reaction and Related Reactions
pp. 1
Fusion of an Aminouracil with a Chloropyridazinecarbonitrile or Pyridazines Having Vicinal Chloro and Carbonyl Groups
pp. 1
Synthesis by Substituent Modification
pp. 1
By Carbofunctional Groups
pp. 1
Oxidation of Dihydro Compounds
pp. 1
Cyclization of 2-Heterosubstituted 6-Aminopyrimidin-4(3)-ones, Aldehydes, and Active Methylene Compounds
pp. 1
Alkoxy, Aryloxy, Alkylsulfanyl, and Arylsulfanyl Group Transformations
pp. 1
Dehydrogenation of Dihydropyrazines and Oxidative Chlorination of Piperazine-2,5-diones
pp. 1
Of Pyrrolo[3,4-]pyridinones
pp. 1
Cyclization of -Carbamoyl--vinylbenzimidamides
pp. 1
Modification of Substituents
pp. 1
From 2-Aminophenyl Ketones and Nitriles
pp. 1
By Formation of Two C—C Bonds
pp. 1
Oxidation of Pyridazino[4,5-]quinoline
pp. 1
By Formation of One C—C Bond
pp. 1
By Amination
pp. 1
Amination, Azidation, and Phosphonation
pp. 1
By Formation of Two Se—C Bonds
pp. 1
Reaction Promoted by Boron Trifluoride
pp. 1
With a Guanidine or Thiourea
pp. 1
Oxidation Using Hydrogen Peroxide
pp. 1
2-Chloroquinoxalines from Anilides under Vilsmeier Conditions
pp. 1
Fragment N—C—C—C—C—N
pp. 1
Substitution of Existing Substituents
pp. 1
Ring Transformation of Pyridazines, 1,2,4-Triazines, or 1,2,5-Oxadiazines
pp. 1
Base-Catalyzed Cyclization of Uracils with Nitriles
pp. 1
Reduction of a Nitro Group
pp. 1
By Transpurination
pp. 1
Condensation of 6-Aminouracils with Aldehydes and Acetoacetates
pp. 1
3-Aminoacrylonitriles
pp. 1
Nitration
pp. 1
Deoxidative Chlorination of Pyrazine -Oxides
pp. 1
Cyclization with Diethoxymethyl Acetate
pp. 1
Synthesis by Substituent Modification
pp. 1
Oxidation of Dihydrophthalazines
pp. 1
By Carbon Nucleophiles via Nucleophilic Substitution
pp. 1
By Carbon Substituents via Cross-Coupling Reactions
pp. 1
Bromination
pp. 1
Synthesis by Ring Transformation
pp. 1
Direct Amination
pp. 1
From -Aryl-′-ylidenebenzimidamides and Enamines, Aldehydes, or Ketenes
pp. 1
By Thiation
pp. 1
Of Carbon Functionalities
pp. 1
Nitration of Dibenzo[,][1,4]dioxins
pp. 1
Halogenation
pp. 1
Addition of Alkyl Groups
pp. 1
Reaction of 1,4-Dithiin-2,3,5,6-tetracarbonitrile with Sulfur
pp. 1
Intramolecular Cyclization of -(Aminocarbonothioyl)-2-chloronicotinamides
pp. 1
Intramolecular Cyclization of a C—N—C—C—N—C Fragment
pp. 1
Reaction of 1-Aryl-2-nitroprop-1-enes with Acetoacetic Acid Derivatives and Hydrazine
pp. 1
At a Ring Nitrogen Atom of a Phthalazinone
pp. 1
From Benzene-1,2-diamines and α-Oxo Acids and Derivatives (The Hinsberg Reaction)
pp. 1
From Benzisoxazole Derivatives
pp. 1
By Ring Contraction
pp. 1
From 2-Aminobenzonitriles and Nitriles
pp. 1
Oxidation
pp. 1
Aminopurines
pp. 1
Palladium-Catalyzed Cross Coupling with Organostannanes (Stille Reaction)
pp. 1
Via an Aza-Wittig-Type Reaction
pp. 1
From 1,3-Oxazines
pp. 1
Synthesis by Substituent Modification
pp. 1
By Formation of Two S—C Bonds
pp. 1
Synthesis from ()-1,2-Dichloroethene and Sodium Sulfide
pp. 1
Synthesis of a Substituted 1,2-Dithiin
pp. 1
By Formation of Three N—C Bonds
pp. 1
Modification of Substituents
pp. 1
Synthesis by Substituent Modification
pp. 1
Chlorination
pp. 1
By Halogen Exchange
pp. 1
Synthesis from 5-Unsubstituted Pyrimidin-4-amines
pp. 1
Alkylation
pp. 1
Reactions of Malonaldehyde Diacetals
pp. 1
By Diels—Alder Cyclization
pp. 1
From a 1,2-Bifunctional Compound and Ammonia or Ammonium
pp. 1
Oxidation with Peracids
pp. 1
By Substitution of Halogen Atoms
pp. 1
Quinoxaline 1,4-Dioxides from Benzofuroxan and Dienamines
pp. 1
Cyclization with Ortho Esters and Diethoxymethyl Acetate
pp. 1
From 2-Aminobenzonitriles, Grignard Reagents, and Carbonyl Compounds or Phosgene Iminium Chlorides
pp. 1
Fragment Arene—N—C—C—N
pp. 1
Reaction of 3-Sulfanyl-Substituted Prop-2-en-1-ones
pp. 1
From 3-1,2,3-Triazolo[4,5-]pyrimidin-3-amines and 2,3,4,5-Tetraarylcyclopentadienone
pp. 1
Condensation of 4,5-Dicarbofunctional Pyridazines with Amines
pp. 1
Reaction of Malononitrile
pp. 1
Reaction of 1-Pyrrolo[3,4-]pyridine-1,3(2)-diones with Hydrazines
pp. 1
From 2-Isocyanato- or 2-Isothiocyanatobenzonitriles
pp. 1
Fragment Arene—N—N—C—C
pp. 1
Fragments C—C—N—C—C and N
pp. 1
Halogen Group Transformations
pp. 1
Alkylation of 2-Bromo-1,4-benzodioxin by Lithium–Halogen Exchange
pp. 1
By Formation of Two S—C Bonds and One C—C Bond
pp. 1
From 1,2,3-Benzotriazin-4(3)-ones
pp. 1
Protonation
pp. 1
From 2,3-Dihaloquinones
pp. 1
Intermolecular [4 + 2] Cycloadditions of 1,2,4-Triazines with Imidazoles
pp. 1
Acid-Promoted Cyclization of Azines
pp. 1
From α-Amino Amides
pp. 1
Fragments N—N—C—C and C—C
pp. 1
From -[2-(1-Amino-3-oxoalk-1-enyl)phenyl]acetamides
pp. 1
Cyclization of Pyridine-3,4-dicarboxamides with Rearrangement
pp. 1
From Imidoyl Isocyanates, Imidoyl Isothiocyanates, Imidoylcarbodiimides, or Imidoylketenimines
pp. 1
Reaction of Ethyl (Cyanoacetyl)carbamate with Trifluoroacetonitrile
pp. 1
From Trifluoromethanesulfonates or 4-Toluenesulfonates
pp. 1
With Two One-Carbon Carbonyl Fragments or Their Equivalents
pp. 1
Synthesis from 1-Bromo-4-phenoxybut-2-yne and Sodium Sulfide
pp. 1
Substitution of Existing Substituents
pp. 1
Introduction of Sulfur Substituents
pp. 1
By Ring Enlargement of Oxadiazoles or Thiazoles
pp. 1
Intramolecular Cyclization of 2-Substituted 3-Hydrazonopyridines
pp. 1
Reaction of Heterosubstituted Alkenes
pp. 1
By Reductive Cleavage of Substituents
pp. 1
Fragments N—C—Arene—N and C
pp. 1
Intramolecular Cyclization of 3-(Acetylamino)pyridine-2-carboxamides or 3-(Acetylamino)-2-pyridyl Oximes
pp. 1
Cyclization with Trifluoroacetic Acid
pp. 1
From Benzisothiazole Derivatives
pp. 1
With Alkylcuprates
pp. 1
Bromination
pp. 1
With S-Nucleophiles
pp. 1
From 4,5-Disubstituted Pyridazines
pp. 1
Of Carbon Functionalities
pp. 1
Fragment N—N—Arene—C—C
pp. 1
Cyclization of 4-Vinylpyridin-3-amines by Diazotization
pp. 1
Synthesis by Ring Transformation
pp. 1
Pyrido[2,3-]pyridazines
pp. 1
Aromatization
pp. 1
Propynenitriles and Buta-2,3-dienenitriles
pp. 1
By Reduction
pp. 1
Quaternization
pp. 1
Phenazin-2-ol 5,10-Dioxides from Benzofurazan 1-Oxides and Phenolates
pp. 1
From 2,6-Disubstituted Pyrimidin-4-amines
pp. 1
Deoxygenation of -Oxides and Reductive Removal of Oxygen Functionalities
pp. 1
Reaction with -Methyluronium Salts
pp. 1
Synthesis by Substituent Modification
pp. 1
Fragments N—C—C and N—C—C
pp. 1
By Ring Enlargement
pp. 1
From 2-Hydroxy-4-oxo Acids
pp. 1
Addition Reactions
pp. 1
Oxidation of 3,4-Dihydroquinoxalin-2(1)-one Derivatives
pp. 1
By Ring Enlargement of Benzofurazan 1-Oxides
pp. 1
By Removal of Substituents
pp. 1
Introduction of a Sulfur Functionality
pp. 1
Formation of Radical Cations
pp. 1
Fragment N—N—C—Arene—C
pp. 1
Synthesis from Non-heterocyclic Substrates
pp. 1
Of Carbon Functionalities
pp. 1
Reaction of Enol Trifluoromethanesulfonates
pp. 1
By Formation of Two S—C Bonds
pp. 1
Phenazine-1-carboxylic Acids by Reductive Cyclization of 3-Nitro--phenylanthranilic Acids
pp. 1
Fragments N—Arene—N and C—C
pp. 1
Fragments C—C—S—C and C—S
pp. 1
Cyclization of 5-(4-Aminopyrimidin-5-yl)-1-imidazole-4-carbonitriles
pp. 1
Oxidation Using Benzenediazonium Salts
pp. 1
Fragments C—N—C and C—N—C
pp. 1
Alkylation
pp. 1
Via an Alkyl or Silyl Lactim Ether (The Hilbert–Johnson Reaction)
pp. 1
Oxo Group Transformations
pp. 1
From 2-(Acylamino)benzamide Oximes, 2-(Acylamino)benzaldehyde Oximes, or Hydrazones and 2-(Acylamino)phenyl Ketone Oximes or -Acylhydrazones
pp. 1
Fragments O—C—C—O and C—C
pp. 1
Synthesis from 2-Chloro-1-phenylethane-1,1-dithiol and Sodium Sulfide
pp. 1
Condensation of 1,2-Diacylbenzenes and Phthalaldehyde Derivatives with Hydrazine
pp. 1
By Ring Contraction
pp. 1
From 2-Aminobenzamides and Aldehydes
pp. 1
From Substituted Sodium Thiosulfates
pp. 1
Fragments O—C—C and O—C—C
pp. 1
Cyclization of 3-Aminopyridine-2-carboxamides with Acetals
pp. 1
Syntheses from 5-Aminoimidazole-4-carboximidamide Derivatives
pp. 1
By N-Glycosylation
pp. 1
Fragment C—O—C—C—O—C
pp. 1
Of Metals
pp. 1
From Substituted Pyridazines
pp. 1
Condensation of 2-Halonicotinates with Ureas and Amidines
pp. 1
5-Substituted 1,4-Benzodioxins via Lithiation of η-Chromium(0) Complexes of 1,4-Benzodioxins
pp. 1
Use of Glyoxal and Its Equivalents
pp. 1
From Cinnolines
pp. 1
Synthesis by Ring-Closure Reactions
pp. 1
Modification of Existing Substituents
pp. 1
Of Hydrogen
pp. 1
From Acyclic Precursors
pp. 1
Of Carbon Substituents
pp. 1
Synthesis of 1,2-Dithiin
pp. 1
Cyclocondensation of 4-Amino-6-methylpyridazine-3-carbaldehyde with Ketones
pp. 1
By Lithiation-Based Electrophilic Substitution
pp. 1
Reaction of 3-Chloroacrylonitriles with Nitriles
pp. 1
Hydroxylation and Alkoxylation
pp. 1
By Annulation to an Arene
pp. 1
Condensation of 3-Aminopyridine-2-carboxylates with Isocyanates
pp. 1
Modification of Carbon Substituents
pp. 1
Cyclization of 1-Benzylpiperidin-4-one, Nitriles, and Trifluoromethanesulfonic Anhydride
pp. 1
Intramolecular Cyclization of 3-[(2-Aminophenyl)amino]-2-chlorobut-2-enenitrile
pp. 1
N-Oxidation
pp. 1
Deoxidative Sulfanylation of Pyrazine -Oxides
pp. 1
Synthesis by Ring-Closure Reactions
pp. 1
Cycloamination of 3-Isocyanatopyridine-2-carboxylates
pp. 1
From 4-(Acylamino)pyrimidine-5-carbonitrile
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