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Inflamed lung in vitro co-culture models by Ana Margarida Martins Maia Costa

Articles in acute lung injury, in vitro cell models, cell co-cultures and inflamation of the lung.

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Hallmarks of acute lung innjury include dysfunction of the alveolar-capillary membrane resulting in increased vascular permeability, an influx of inflammatory cells into the lung and a local pro-coagulant state. The syndrome has a mortality rate of approximately 35% and usually requires invasive mechanical ventilation.  Improved animal models and the development of human in vivo and ex vivo models are therefore required.

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