Although there is an obvious link between digestive disorders and the microbial population in the human gut, also less obvious connections with diseases like autism, depression, Chronic fatigue Syndrome, Astma, Allergies, multiple sclerosis and others.
An excellent overview of the role of microbes of the human gut is given in "Follow your Gut" from Rob Knight. (Ted Books, Simon & Schuster 2015, ISBN 978-1-47113-890-4).
The case of autism is especially intriguing. At Caltech Sakus Mazmanian has created a treatment for mice with autism like symptoms, which consists of giving mice a probiotic strain of Bacteroides fragilis that reverses part of the symptoms like gastro-intestinal issues and cognitive deficits typical for autism (Follow your gut , chapter 4).
In a recent study Laura Steenbergen of Leiden University showed that Multispecies probiotics may be used as potential preventive strategy for depression (see article link below)
In another study and coworkers demonstrated that patients with major depressive disorders harbored distinct microbiota in their guts.
Many more relations between human disease conditions and microbial compositions in the human gut are constantly being discovered. Especially the mapping of the human gut microbiome has opened up new avenues for research into the relationships between specific microbes and human diseases.
The present collection shows a selection of articles ranging from human microbiome studies to soil microbiota and the interplay between microbes in the soil and in the human gut highlighting their effects on soil and plant health and human health.
A consequence of the growing insight into the dependancy of human health on healthy microbial populations in the gut is that the use of antibiotics is seen in another light.
In his book "missing microbes" ( Henry Holt Publ. 2014, ISBN 9780805098105), Martin Blaser explains at lenght the inherent danger of antibiotic abuse. According to him overuse of antibiotics is fueling our modern plagues.
Although the human gut seems to bear the most influence on human health we should bear in mind that all other body parts harbor many diverse species of microbes. The composition of human skin microbiota for instance have a big effect on skin conditions .
In fact there are 10 x more microbial cells in the human body as human tissue cells. Seen from a genetic perspective, the 21,000 human genes are complemented by the 4.4 million genes present in the diverse microbiota living in and on us. This means that we are in fact a super-organism where only .5 % of its genes are human. As Alanna Collen phrased it: our body's microbes hold the key to health and happiness ( 10% human, how your body's microbes hold the key to health and happiness, 2015, Harper&Collins, ISBN 9780062345981).
new article in Brain Behaviour and Immunity
A randomized controlled trial to test the effect of multispecies probiotics on cognitive reactivity to sad mood ☆
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