Genome Integrity

Genome Integrity is a peer-reviewed, continuous, open access  journal.

Abstracting and Indexing Information

The journal is indexed with, or included in, the following:
PubMed Central, Scimago Journal Ranking, SCOPUS

Open Access Publication and Creative Commons Licensing

This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0). Users are allowed to share (copy and redistribute the material in any medium or format) and adapt (remix, transform, and build upon the material for any purpose, even commercially), as long as the authors and the publisher are explicitly identified and properly acknowledged as the original source.

Digital Archiving

ScienceOpen provides for long-term digital preservation through a partnership with CLOCKSS.

Genome Integrity is an open access journal that publishes research on all aspects of genome integrity, the cellular processes underlying maintenance of genome stability, and the effects of instability.

The processes that regulate genome integrity maintenance include sensing, signalling and repair of DNA damage, processing of DNA damage in the context of chromatin and chromosomes, cell cycle checkpoint control and control of apoptosis. Effective maintenance of genome integrity is essential for normal cell division, tissue homeostasis, healthy organismal ageing and prevention of diseases such as cancer. A number of model systems including single cell organisms and various higher plant and animal species, as well as studies of human cells/tissues or patients are required to understand how genome integrity maintenance affects ageing and development of cancer.

Subjects covered in the journal

The journal is focused on understanding the processes that regulate the maintenance of genome integrity. Topics include, but are not limited to:

• induction of DNA damage
• sensing, signalling and repair of DNA damage
• processing of DNA damage in the context of chromatin and interphase chromosomes
• chromosome alterations
• telomere maintenance
• cell cycle regulation
• control of apoptosis
• effects of genotoxic stress including radiation and chemicals
• genome integrity and ageing
• genome integrity and cancer
• human genetic disorders
• radiation induced genome instability

Editors-in-Chief

M Prakash HANDE, National University of Singapore

Editorial Board

Frederick Alt, Harvard Medical School, USA

Rhona Anderson, Brunel University, UK

Adayabalam S Balajee, Oak Ridge Institute of Science and Eduation, USA

Maria Blasco, Spanish National Cancer Research Centre (CNIO), Spain

Vilhelm Bohr, National Institute of Aging, USA

Fabrizio d’Adda di Fagagna, IFOM - The FIRC Institute of Molecular Oncology, Italy

Ronald DePinho, MD Aanderson Cancer Center, USA

Yuri Dubrova, University of Leicester, UK

Michael Fenech, Formerly with CSIRO, Australia

Anna Genesca, Autonomous University of Barcelona, Spain

David Gilley, South Dakota School of Mines and Technology, USA

David Gisselsson Nord, Lund University, Sweden

Elena Giulotto, Formerly with University of Pavia, Italy

Razqallah Hakem, Princess Margaret Cancer Centre and University of Toronto, Canada

Xiangwei He, Zhejiang University, China

Jan Hoeijmakers, Erasmus University, The Netherlands

George Iliakis, Institute of Medical Radiation Biology, Germany

Munira Kadhim, Oxford Brookes University, UK

Kum Kum Khanna, QIMR Berghofer Medical Research Institute, Australia

Tom Kirkwood, Newcastle University, UK

Han-Woong Lee, Yonsei University, South Korea

Wilner Martinez Lopez, Clemente Estable Biological Research Institute, Uruguay

Noel Lowndes, National University of Ireland Galway, Ireland

Peter McPherson, University of Toronto, Canada

Ciaran Morrison, National University of Ireland Galway, Ireland

Kalappagowda Muniyappa, Indian Institute of Science, India

Kyungjae Myung, IBS Center for Genomic Integrity  - Ulsan National Institute of Science and Technology, South Korea

Robert Newbold, Brunel University, UK

Tej Pandita, Houston Methodist Research Institute/Baylor College of Medicine, USA

John Petrini, Memorial Sloan Kettering Cancer Center, USA

Kevin Prise, Queen's University Belfast, UK

Roger Reddel, CMRI and University of Sydney, Australia

Kai Rothkamm, University Medical Centre Hamburg, Germany

Laure Sabatier, Atomic Energy and Alternative Energies Commission, France

Ralph Scully, Harvard Medical School, USA

Sagar Sengupta, National Institute of Immunology, India

Predrag Slijepcevic, Brunel University, UK

Keiji Suzuki, Nagasaki University, Japan

Dik van Gent, Erasmus University, The Netherlands

Andrej Wojcik, Stockholm University, Sweden

All manuscripts must be submitted on-line through the "Submit a manuscript" button on this website. First time users will have to register at this site. Registration is free but mandatory. Registered authors can keep track of their articles after logging into the site. If you experience any problems, please contact feedback@scienceopen.com.
A manuscript will be reviewed for possible publication with the understanding that it is being submitted to Genome Integrity alone at that point in time and has not been published anywhere, simultaneously submitted, or already accepted for publication elsewhere. The journal expects that authors would authorize one of them to correspond with the journal for all matters related to the manuscript. All manuscripts received are duly acknowledged. On submission, editors review all submitted manuscripts initially for suitability for formal review. Manuscripts with insufficient originality, serious scientific or technical flaws, or lack of a significant message are rejected before proceeding for formal peer-review.
Manuscripts that are found suitable for publication in Genome Integrity are sent to two or more expert reviewers. During submission, the contributor may provide names of two or three qualified reviewers who have had experience in the subject of the submitted manuscript, but this is not mandatory.
Manuscripts accepted for publication are copy edited for grammar, punctuation, print style, and format. Page proofs are sent to the corresponding author. The corresponding author is expected to return the corrected proofs within three days. It may not be possible to incorporate corrections received after that period. The whole process of submission of the manuscript to final decision and sending and receiving proofs is completed online. 

Authorship credit should be based only on substantial contributions to each of the three components mentioned below: 

1. Concept and design of study or acquisition of data or analysis and interpretation of data;
2. Drafting the article or revising it critically for important intellectual content; and
3. Final approval of the version to be published.

Participation solely in the acquisition of funding or the collection of data does not justify authorship. General supervision of the research group is not sufficient for authorship. Each contributor should have participated sufficiently in the work to take public responsibility for appropriate portions of the content of the manuscript.

All authors of must disclose any and all conflicts of interest they may have with publication of the manuscript or an institution or product that is mentioned in the manuscript and/or is important to the outcome of the study presented. Authors should also disclose conflict of interest with products that compete with those mentioned in their manuscript.

Submitted manuscripts that are not as per the “Instructions to Authors” would be returned to the authors for technical correction, before they undergo editorial/ peer-review. The manuscript should be submitted as a pdf file:

Title Page/First Page This page should provide

1. The type of manuscript (original article, case report, review article, Letter to editor, etc.) title of the manuscript, running title, names of all authors/ contributors.
2. Acknowledgement, if any. One or more statements should specify 1) contributions that need acknowledging but do not justify authorship, such as general support by a departmental chair; 2) acknowledgments of technical help; and 3) acknowledgments of financial and material support, which should specify the nature of the support. This should be included in the title page of the manuscript and not in the main article file.
3. Registration number in case of a clinical trial and where it is registered (name of the registry and its URL)
4. Conflicts of Interest of each author/ contributor. A statement of financial or other relationships that might lead to a conflict of interest, if that information is not included in the manuscript itself or in an authors' form
5. The name, address, e-mail, and telephone number of the corresponding author, who is responsible for communicating with the other authors about revisions and final approval of the proofs, if that information is not included on the manuscript itself.

The main text of the article, beginning from Abstract till References (including tables) should be included in the pdf file.  The pages should be numbered consecutively, beginning with the title page.

Types of Manuscripts

Genome Integrity publishes the following types of articles:

• Original articles - papers reporting results of original, fundamental research and case reports with respect to the scope of the journal.
• Review articles

Structure

The text of original articles should be divided into sections with the headings Abstract, Key-words, Introduction, Material and Methods, Results, Discussion, References, Tables and Figure legends.

References

References should be complete with DOI numbers if possible. Use the style of the examples below, which are based on the formats used by the NLM in Index Medicus. The titles of journals should be abbreviated according to the style used in Index Medicus. Use complete name of the journal for non-indexed journals
The commonly cited types of references are shown here, for other types of references such as newspaper items please refer to ICMJE Guidelines (http://www.icmje.org or http://www.nlm.nih.gov/bsd/uniform_requirements.html).

Articles in Journals: Always provide DOI number when available

1. Standard journal article (for up to six authors): 

Blackburn EH, Epel ES, Lin J. Human telomere biology: A contributory and interactive factor in aging, disease risks and protection. Science 2015; 350(6265): 1193–1198. DOI: 10.1126/science.aab3389

1. Standard journal article (for more than six authors): List the first six contributors followed by et al. 

Alder JK, Hanumanthu VS, Strong MA, DeZern AE, Stanley SE, et al. Diagnostic utility of telomere length testing in a hospital-based setting. Proc Natl Acad Sci U S A. 2018: 115(10): E2358–E2365. DOI: 10.1073/pnas.1720427115.

1. Volume with supplement

Otranto D, Capelli G, Genchi C: Changing distribution patterns of canine vector borne diseases in Italy: leishmaniosis vs. dirofilariosis. Parasites & Vectors 2009; Suppl 1:S2. DOI: 10.1186/1756-3305-2-S1-S2

Books and Other Monographs: Always provide DOI number when available

1. Monograph: Rohela Mahmud, Yvonne Ai Lian Lim, Amirah Amir. Medical Parasitology. Springer. 2017. DOI: 10.1007/978-3-319-68795-7
2. Edited work: Garcia LS (editor). Diagnostic Medical Parasitology. ASM press 2007. DOI: 10.1128/9781555816018
3. Chapter in a book: Khosravi S, Dreissig S, Schindele P, Wolter F, Rutten T, Puchta H, et al. Live-Cell CRISPR Imaging in Plant Cells with a Telomere-Specific Guide RNA. In: RNA Tagging: Methods and Protocols. Springer 2020. 343-356. DOI: 10.1007/978-1-0716-0712-1_20

Tables

• Tables should be self-explanatory and should not duplicate textual material.
• Number tables, in Arabic numerals, consecutively in the order of their first citation in the text and supply a brief title for each.
• Place explanatory matter in footnotes, not in the heading.
• Explain in footnotes all non-standard abbreviations that are used in each table.
• Obtain permission for all fully borrowed, adapted, and modified tables and provide a credit line in the footnote.
• Tables with their legends should be provided at the end of the text after the references. The tables along with their number should be cited at the relevant place in the text

Illustrations (Figures)

• High resolution images will be requested upon acceptance of the manuscript.
• Figures should be numbered consecutively according to the order in which they have been first cited in the text.

It is the responsibility of authors/ contributors to obtain permissions for reproducing any copyrighted material. A copy of the permission obtained must accompany the manuscript.

The revised version of the manuscript should be submitted online in a manner similar to that used for submission of the manuscript for the first time. When submitting a revised manuscript, contributors are requested to include, the ‘referees’ remarks along with point to point clarification at the beginning in the revised file itself. In addition, they are expected to mark the changes as underlined or colored text in the article.

Publication schedule

The journal publishes articles on its website immediately on acceptance and follows a ‘continuous publication’ schedule.

Article processing charge:
The journal charges following fee on acceptance: US $ 500 + taxes

Article publication charge USD 500 which should be paid upon acceptance of the paper. 

Covering letter

• Source of funding mentioned
• Conflicts of interest disclosed

Authors

• Please follow the first, middle and last name order.
• Complete affiliation data provided (Department, Institute, City, Country)
• Author for correspondence, with e-mail address provided

Presentation and format

• Page numbers included at bottom
• Running title provided (not more than 50 characters)
• Abstract provided (ca. 250 words for original articles)
• Key words provided (three or more)
• Introduction
• Materials and Methods
• Results
• Discussion
• Headings in title case

Language and grammar

• Write the full term for each abbreviation at its first use in the title, abstract, keywords and text separately unless it is a standard unit of measure. Numerals from 1 to 10 spelled out
• Numerals at the beginning of the sentence spelled out
• Check the manuscript for spelling, grammar and punctuation errors
• If a brand name is cited, supply the manufacturer's name and address (city and state/country).
• Species names should be in italics

Editor
Dr M Prakash Hande
Department of Physiology,
Yong Loo Lin School of Medicine,
National University of Singapore,
Block MD9, 2 Medical Drive,
Singapore 117593

Email: phsmph@nus.edu.sg

Article processing charge:

The journal charges following processing fee upon acceptance:   USD 500 

Open Access Publishing Agreement

By submitting my manuscript to the journal Genome Integrity published by ScienceOpen (hereafter the ‘Publisher’), I herewith grant permission to the Publisher to publish my article upon editorial acceptance under the following publishing agreement.

I hereby confirm that this is my original work and that

• I own sole copyright in this work
• And/or I have obtained permission from all other Authors to execute this Agreement on their behalf if necessary

And that the work

• Has never been published before.

I understand that in granting this consent I am granting to the Publisher the Rights to publish under a Creative Commons CC-BY 4.0 license the Contribution in the English language in digital form; moral rights will be retained by the original Author/s and copyright will be held by the Author.

I agree to this Publishing Agreement, consent to execution and delivery of the Publishing Agreement electronically and agree that confirming my consent electronically during the manuscript submission process with an electronic signature shall be given the same legal force as a handwritten signature.

Terms of Use

1. The Contribution will be made Open Access under the terms of the Creative Commons Attribution License (CC-BY License) which permits use, distribution and reproduction in any medium, provided that the Contribution is properly cited.
2. The Journal (and Publisher) reserves the right to require changes to the Contribution, including changes to the length of the Contribution, as a condition of its acceptance. The Journal (and Publisher) reserves the right, notwithstanding acceptance, not to publish the Contribution if for any reason such publication would in the reasonable judgment of the Journal (and Publisher), result in legal liability or violation of journal ethical practices. If the Journal (or Publisher) decides not to publish the Contribution, the Author is free to submit the Contribution to any other journal from any other publisher.
3. As above, the final Contribution will be made Open Access under the terms of the CC-BY license. Reproduction, posting, transmission or other distribution or use of the final Contribution in whole or in part in any medium by the Author as permitted by this Agreement requires a citation to the Journal suitable in form and content as follows: (Title of Contribution, Author, Journal Title and Volume/lssue, Digital Object Identifier (DOI), Date). Links to the final published Contribution should be provided following the guidance below on best practice.

Retained Rights

The Author retains all proprietary rights in addition to copyright, such as patent rights in any process, procedure or article of manufacture described in the Contribution.

Author's Representations

The Author(s) certify that they have participated sufficiently in the intellectual content, conception and design of this work or the analysis and interpretation of the data (when applicable), as well as the writing of the manuscript, to take public responsibility for it and have agreed to have their name listed as a contributor. The Author(s) believe the manuscript represents valid work. Neither this manuscript nor one with substantially similar content under their authorship has been published or is being considered for publication elsewhere, except as described in the covering letter. The Author(s) certify that all the data collected during the study is presented in this manuscript and no data from the study has been or will be published separately. If requested by the editors, the Author(s) will provide the data/information or will cooperate fully in obtaining and providing the data/information on which the manuscript is based, for examination by the editors or their assignees. Financial interests, direct or indirect, that exist or may be perceived to exist for individual contributors in connection with the content of this paper have been disclosed in the cover letter. Sources of outside support of the project are named in the cover letter.

Use of Information

The Author(s) acknowledges that, during the term of this Agreement and thereafter (for as long as necessary), the Publisher and the Journal may process the Author’s personal data, including storing or transferring data outside of the country of the Contributor’s residence, in order to communicate with the Author(s) and that the Publisher has a legitimate interest in processing the Author(s)’ personal data. By entering into this Agreement, the Author(s) agree to the processing of personal data (and, where applicable, confirms that the Author has obtained the permission from all other authors to process their personal data). The Publisher and the Journal shall comply with all applicable laws, statutes and regulations relating to data protection and privacy and shall process such personal data.