HLA-G and immune tolerance in pregnancy

HLA-G and immune tolerance in pregnancy: Milestones

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Use of HLA loss mutants to analyse the structure of the human major histocompatibility complex 

Evidence for a novel HLA antigen found on human extravillous trophoblast and a choriocarcinoma cell line. 

A human major histocompatibility complex class I gene that encodes a protein with a shortened cytoplasmic segment 

Nomenclature for factors of the HLA system, 1989. 

A class I antigen, HLA-G, expressed in human trophoblasts 

Resistance of HLA-G and HLA-A2 transfectants to lysis by decidual NK cells. 

The membrane-bound and soluble forms of HLA-G bind identical sets of endogenous peptides but differ with respect to TAP association. 

Protection from Natural Killer Cell-Mediated Lysis by HLA-G Expression on Target Cells 

A human histocompatibility leukocyte antigen (HLA)-G-specific receptor expressed on all natural killer cells 

Transcriptional regulation of the MHC class Ib genes HLA-E, HLA-F, and HLA-G. 

Altered HLA-G transcription in pre-eclampsia is associated with allele specific inheritance: possible role of the HLA-G gene in susceptibility to the disease 

Disulfide bond-mediated dimerization of HLA-G on the cell surface. 

Crystal structure of HLA-G: a nonclassical MHC class I molecule expressed at the fetal-maternal interface. 

Activation of NK cells by an endocytosed receptor for soluble HLA-G 

Immune regulation by pretenders: cell-to-cell transfers of HLA-G make effector T cells act as regulatory cells 

Cellular senescence induced by CD158d reprograms natural killer cells to promote vascular remodeling. 

A distant trophoblast-specific enhancer controls HLA-G expression at the maternal-fetal interface. 

HLA-G: from biology to clinical benefits 

HLA-G: At the Interface of Maternal-Fetal Tolerance. 


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