Article on cell culture models of the lung, especifically for the deep lung, in the alveolar region. Includes healhty and disease models.
After acute lung injury, altered bronchioloalveolar epithelia must be repaired quickly in order to restore lung function. During reepithelialization, type II cells initially appear to migrate and spread over a remodeled matrix; then a secondary proliferative phase occurs. It was hypothesized that 1) type II cells can develop locomotion in vitro that is modulated by growth factors, proinflammatory cytokines, and substrate adhesion molecules and 2) migration and proliferation of type II cells can occur as distinctive processes.
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|ScienceOpen disciplines:||Cell biology, Anatomy & Physiology, Respiratory medicine, Pharmacology & Pharmaceutical medicine|
|Keywords:||cell culture, airways, alveolar region|