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    Review of 'Organocatalysts for enantioselective synthesis of fine chemicals: definitions, trends and developments'

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    Average rating:
        Rated 3.5 of 5.
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        Rated 4 of 5.
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        Rated 3 of 5.
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        Rated 3 of 5.
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    Organocatalysts for enantioselective synthesis of fine chemicals: definitions, trends and developments

    Organocatalysis, that is the use of small organic molecules to catalyse organic transformations, has been included among the most successful concepts in asymmetric catalysis and it has been used for the enantioselective construction of C-C, C-N, C-O, C-S, C-P, and C-halide bonds. Since the seminal works in early 2000, the scientific community has been paying an ever-growing attention to the use of organocatalysts for the synthesis, with high yields and remarkable stereoselectivities, of optically active fine chemicals of interest for the pharmaceutical industry. A brief overview is here presented about the two main classes of substrate activation by the catalyst: covalent organocatalysis and non-covalent organocatalysis, with a more stringent focus on some recent outcomes in the field of the latter and of hydrogen-bond-based catalysis. Finally, some successful examples of heterogenisation of organocatalysts are also discussed, in the view of a potential industrial exploitation.
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      Review information

      10.14293/S2199-1006.1.SOR-CHEM.AGZIIB.v1.REUGSR

      This work has been published open access under Creative Commons Attribution License CC BY 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Conditions, terms of use and publishing policy can be found at www.scienceopen.com.

      Review text

      This review article titled “Organocatalysts for enantioselective synthesis of fine chemicals: definitions, trends and developments” gave a brief overview about the two main classes of substrate activation by the catalyst and some successful examples of heterogenisation of organocatalysts were also discussed. This is in general a not bad review for those who have just entered the area of organocatalysis. I would agree the publication of the current review unless the following corrections were made:

      First, I supposed more detailed about the reaction mechanism should be given for those beginners in this area to understand the process of the reaction and the working mode of the catalysts (such as Figure 6, 12-14, 16 and so on).

      Second, ambiguous or incorrect presentations were found now and then. For examples, in Figure 10, the phrase “Bronsted base” should have been “Brønsted base”; in figure 11, the Schereiner thiourea was not a chiral catalyst at all; the absolute configuration of compound 40, 59, 61 were not specified; in figure 12, all reactions were catalyzed by “catalyst” but we don’t know by which catalyst; in Figure 16, the catalyst loading was not given.

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