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    Review of 'Vaccination and autoimmune disease: what is the evidence?'

    Vaccination and autoimmune disease: what is the evidence?Crossref
    Authors make unsupported assumption on the role of autoimmune fail-safe mechanisms in vaccination
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    Vaccination and autoimmune disease: what is the evidence?

    As many as one in 20 people in Europe and North America have some form of autoimmune disease. These diseases arise in genetically predisposed individuals but require an environmental trigger. Of the many potential environmental factors, infections are the most likely cause. Microbial antigens can induce cross-reactive immune responses against self-antigens, whereas infections can non-specifically enhance their presentation to the immune system. The immune system uses fail-safe mechanisms to suppress infection-associated tissue damage and thus limits autoimmune responses. The association between infection and autoimmune disease has, however, stimulated a debate as to whether such diseases might also be triggered by vaccines. Indeed there are numerous claims and counter claims relating to such a risk. Here we review the mechanisms involved in the induction of autoimmunity and assess the implications for vaccination in human beings.

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      This work has been published open access under Creative Commons Attribution License CC BY 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Conditions, terms of use and publishing policy can be found at www.scienceopen.com.

      Autoimmune Diseases,etiology,Autoimmunity,immunology,Humans,Infection,complications,immunology,Molecular Mimicry,Risk,Vaccination,adverse effects,Vaccines,adverse effects,immunology
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      Review text

      The authors assume that fail-safe mechanisms operational during natural infections, apply equally to the host response to vaccination.

      They cite no reference or explain why that is true. Details below:

      Flawed assumptions fuel autoimmune disease: The sorry state of vaccine safety science



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