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    Review of 'SGLT-2 inhibitors may increase ultrafiltration in incident peritoneal dialysis patients: a case report'

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    SGLT-2 inhibitors may increase ultrafiltration in incident peritoneal dialysis patients: a case reportCrossref
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    SGLT-2 inhibitors may increase ultrafiltration in incident peritoneal dialysis patients: a case report

    Background Adequate fluid removal to achieve euvolemic status can be difficult in patients with incident peritoneal dialysis (PD). Limited treatments such as increased high dextrose PD solutions and icodextrin are currently available. We reported four incident PD patients whose’ ultrafiltration volume was increased after sodium-glucose cotransporter-2 inhibitors. Case presentation. The four reported cases were diabetic kidney disease stage 5 (cases 1–3) and IgA nephritis (case 4) patients whostartedt PD because of acute pulmonary edema (case 1 and 3), nausea vomiting (case 2), and hyperkalemia (case 4). They had an ultrafiltration volume of 700-1000 ml per day but hpersistentted peripheral pitting edema or pulmonary edema. Their ultrafiltration volincreased after dapagliflozin 5 mg daily, and the fluid overload symptoms ere improved. No hypotension, or hypoglycemia was found, and the urine was not increased during dapagliflozin treatment. Conclusions SGLT-2 inhibitors may increase ultrafiltration in incident PD patients. More studies are needed to support the safety of SGLT-2 inhibitors in PD patients.
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      10.14293/S2199-1006.1.SOR-MED.A10122385.v1.RQIMYB
      This work has been published open access under Creative Commons Attribution License CC BY 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Conditions, terms of use and publishing policy can be found at www.scienceopen.com.

      Nephrology
      sglt-2 inhibitors,peritoneal dialysis,case report,ultrafiltration
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