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    Review of 'Autism Revisited: (expanded 2022 version) <br/>Serendipitous Observations and Theory Relevant To Autism'

    Autism Revisited: (expanded 2022 version) <br/>Serendipitous Observations and Theory Relevant To AutismCrossref
    Although there is no confirmatory experiment, the viewpoint is novel and rigorous,
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    Autism Revisited: (expanded 2022 version)
    Serendipitous Observations and Theory Relevant To Autism

    It is hypothesized that the measles N protein component of the attenuated (vaccine derived) measles virus, chronically interfers with a specific homeostatic mechanism that provides balance between metabolic and immune function, resulting in autism. First, congenital metabolic diseases or risk factors, produce primary LOCAL and CONTINUING SUPPRESSIONS of enzymatic and immune functions. Critical among these risk factors is extremely low or non-existent secretory IgA. Second, the overall cellular homeostatic environment is then severely affected by GLOBAL and TRANSIENT metabolic and immune SUPPRESSIONS from the attenuated measles vaccination. Third, the combined effects of severe immune/enzymatic suppressions from the attenuated measles virus, severely reduced IgA, and other CMD's, allows opportunistic infections to flourish, which support secondary immune and enzyme suppressions. Finally, all these suppressions produce a severe intracellular messenger-metabolite flux reduction, which allows the attenuated measles N protein freedom to interact, and interfere with, the eukaryotic initiation factor eIF3P40. eIF3P40 is joined to the eukaryotic initiation factor eIF4E through an eIF4G linkage. Theoretically, this would create a severe dysregulation in the eukaryotic initiation factor eIF4E, which has been observed in autistic children, and associated with autistic behavior in animal studies. This severe messenger-metabolite flux reduction from reduced secretory IgA and other CMD's, immune repression from opportunistic infections and consequent and continuing attenuated measles virus latency, results in an ongoing inability to achieve homeostasis between metabolic functions and immune functions. This manifests as autism. Three tests of this theory are possible. First, treatment with vaccine derived (attenuated) measles N protein specific secretory immunoglobulin A, which is capable of neutralizing the interference. Theoretically, such a test/treatment would restore homeostasis, with a gradual improvement of the autistic condition. Second, it is proposed that if (vaccine derived) attenuated measles N protein specific IgA is properly administered concurrent to infant measles vaccination, few if any cases of autism should be observed, while still providing protection against measles. Third, immunization of the mother with MMR vaccine and subsequent immunization of the child during concurrent breastfeeding. Theoretically, children could then receive sufficient attenuated measles specific secretory IgA via breast milk with few if any cases of autism (or measles) observed. If correct, these tests could provide empirical evidence of an indirect relationship between autism and attenuated measles virus/vaccination.

      Review information

      This work has been published open access under Creative Commons Attribution License CC BY 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Conditions, terms of use and publishing policy can be found at www.scienceopen.com.

      Life sciences
      autism research and theory,autism research 2022,autism research,Autism Spectrum Disorder and autism theory,MMR and autism theory,measles and autism,autism theory,autism preprint,autism

      Review text

      Although the author did not display statistical tables and relevant test pictures, such as adjusting the concentration ratio of Saccharomyces cerevisiae and soy milk, the time span, and the changes of some factors in the subjects, such as sec IgA, eIF40, phase I, II enzymes, Th1/2, etc., nor did he do relevant confirmatory experiments. Similar subjects or animal experiments, although many of the author's conclusions are based on the data derived from existing literature, they are clear, logical, and rigorous It is undeniable that the author's point of view is very novel and meaningful!


      As the parents of an autistic child, in addition to worrying about the treatment of the child's disease, they also conducted in-depth exploration and treatment, and discovered the potential problems of measles vaccine immunization, and even combed out the possible mechanism behind it! This is not easy. The author also put forward suggestions for vaccination on this basis, which is also beneficial for the follow-up healthy vaccination and side effect screening, and can find the problems of the vaccine itself, improve the composition of the vaccine, and promote medical and scientific research.


      It's nothing to challenge the authority. The authority should be able to withstand scrutiny. If the authority is really credible, the scientific will finally give a clear answer. If the authority only negates and covers up the scientific facts that have been discovered by its own status, it is pseudoscience, and everyone should be punished!


      Minor questions:


      1. Why are there two Discussion 5 titles?


      2. I have never seen the writing format of this article before. The articles I encounter are generally abstracts, introductions, experiments, results, and discussions. Maybe I have read less literature!


      In response to previous peer reviews, I discussed the reasoning 
      behind the length of my work, approach to content, and non-standard 
      organizational format. In responding to my third peer review, I chose
      to discuss the fundamental reasoning that lead to this research, and 
      how this reflects on the lack of statistical tables, confirmatory 
      experiments, pictures, et al. 

      The word "serendipitous" begins this paper, and refers to fortuitous or 
      lucky discoveries (or observations in this case) not sought for. Such
      was the case as I began my research.

      I began by researching for autism treatment options that would lead to 
      positive outcomes. Descriptions of the biophysical effects of these various 
      preperations and supplements would often be listed. After eliminating the 
      psychotropic mwdications, the remaining treatments displayed a curious and 
      unexpected pattern. Autism treatments appeared to either enhance or suppress 
      enzyme production, or enhance or suppress immune function. This fortuitous 
      observation, lead to further investigations into the biophysical nature 
      of autism. Other researchers had previously noted  many immunological 
      and enzymatic irregularites in autistic children not found in atypical 
      children. It seemed reasonable therefore, that if these biophysical 
      abnormalities could be corrected, the autistic condition might be improved. 
      Administration of such supplements however, would frequently produce 
      first a positive outcome, and then with increasing dosage, a negative 
      outcome. This was regardles of whether they were immune or enzymatic 
      response enhancing or reducing. My initial conclusions were that either 
      autism was caused by two problems fundamental to both enzyme and immune 
      production/regulation, or one problem that existed somewhere between 
      these two broad and complex processes.

      After  prolonged study of all the candidate supplements, two appropriate 
      and contrasting preperations were chosen. Both were commonly available 
      and generally considered benign in nature. Saccharomyces cerevisiae (ordinary 
      beer yeast), supported phase II enzyme pruduction. In opposition, plain soy 
      milk which enhanced the TH2 portion of the immune system was also chosen. 
      Homeopathic dosages which resulted in no changes whatsoever were gradually 
      increased untill observable changes were produced. It quickly became evident 
      that I could modify teenager X autism at will by alternating these two 
      supplements. These observations led to only one reasonable conclusion. Some 
      balencing mechanism intermediate to both metabolism and immunity was 
      compromised. After several years of extensive research in the published 
      literature, I was then able to expanded my hypothesis into a comprehensive 
      theory for the prevention and treatment of autism, as well as a theoretical  
      intrinsic mechanism.

      As a result, several of the  common aspects of research papers such as 
      statistical references, additional experiments, variable manipulation, or 
      pictures, did not appear appropriate to this work. 

      Lastly, the double title in Discussion 5, reflected on the most critical 
      arguement against my research conclusions. It became clear that without a
      comprehensive and detailed explanation of how non-vaccinated children become 
      autistic, and why the majority of vaccinated children do not become autistic, 
      my entire theory would be questionable. After an additional year of research, 
      a second and more comprehensive version of my work emerged. It is hoped that 
      all possible questions regarding this theory and the paper that contains it, 
      have now been reasonably answered. It awaits testing.


      2023-03-18 04:56 UTC

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