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    Review of 'Predicting progression to Alzheimer’s disease with human hippocampal progenitors exposed to serum'

    Predicting progression to Alzheimer’s disease with human hippocampal progenitors exposed to serumCrossref
    Muy científico y académico
    Average rating:
        Rated 5 of 5.
    Level of importance:
        Rated 5 of 5.
    Level of validity:
        Rated 5 of 5.
    Level of completeness:
        Rated 5 of 5.
    Level of comprehensibility:
        Rated 5 of 5.
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    Reviewed article

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    • Article: found
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    Predicting progression to Alzheimer’s disease with human hippocampal progenitors exposed to serum

    Abstract Adult hippocampal neurogenesis is important for learning and memory and is altered early in Alzheimer’s disease. As hippocampal neurogenesis is modulated by the circulatory systemic environment, evaluating a proxy of how hippocampal neurogenesis is affected by the systemic milieu could serve as an early biomarker for Alzheimer’s disease progression. Here, we used an in vitro assay to model the impact of systemic environment on hippocampal neurogenesis. A human hippocampal progenitor cell line was treated with longitudinal serum samples from individuals with mild cognitive impairment, who either progressed to Alzheimer’s disease or remained cognitively stable. Mild cognitive impairment to Alzheimer’s disease progression was characterized most prominently with decreased proliferation, increased cell death and increased neurogenesis. A subset of ‘baseline’ cellular readouts together with education level were able to predict Alzheimer’s disease progression. The assay could provide a powerful platform for early prognosis, monitoring disease progression and further mechanistic studies.

      Review information

      This work has been published open access under Creative Commons Attribution License CC BY 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Conditions, terms of use and publishing policy can be found at www.scienceopen.com.

      alzheimer’s disease,neurogenesis,hippocampal progenitors,prognostic biomarker

      Review text

      The publication is relevant to the academic community and provides important information.

      The work represents a new approach or new findings compared to other publications in the field.

      The hypothesis is clearly formulated.

      It is the strict argument. The data is robust, well controlled, and statistically significant.

      The interpretation is balanced and supported by the data. Appropriate and state-of-the-art methods are used.

      The authors refer to the appropriate academic context.

      The authors provide or cite all the information to follow their findings or argumentation.

      They cite all relevant publications in the field.

      The language is correct and easy to understand for an academic in the field.

      The figures are well displayed and the titles are correctly described.

      The article is organized systematically and logically.


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