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    Review of 'Autism Revisited: (expanded 2022 version) <br/>Serendipitous Observations and Theory Relevant To Autism'

    Autism Revisited: (expanded 2022 version) <br/>Serendipitous Observations and Theory Relevant To AutismCrossref
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    Autism Revisited: (expanded 2022 version)
    Serendipitous Observations and Theory Relevant To Autism

    It is hypothesized that the measles N protein component of the attenuated (vaccine derived) measles virus, chronically interfers with a specific homeostatic mechanism that provides balance between metabolic and immune function, resulting in autism. First, congenital metabolic diseases or risk factors, produce primary LOCAL and CONTINUING SUPPRESSIONS of enzymatic and immune functions. Critical among these risk factors is extremely low or non-existent secretory IgA. Second, the overall cellular homeostatic environment is then severely affected by GLOBAL and TRANSIENT metabolic and immune SUPPRESSIONS from the attenuated measles vaccination. Third, the combined effects of severe immune/enzymatic suppressions from the attenuated measles virus, severely reduced IgA, and other CMD's, allows opportunistic infections to flourish, which support secondary immune and enzyme suppressions. Finally, all these suppressions produce a severe intracellular messenger-metabolite flux reduction, which allows the attenuated measles N protein freedom to interact, and interfere with, the eukaryotic initiation factor eIF3P40. eIF3P40 is joined to the eukaryotic initiation factor eIF4E through an eIF4G linkage. Theoretically, this would create a severe dysregulation in the eukaryotic initiation factor eIF4E, which has been observed in autistic children, and associated with autistic behavior in animal studies. This severe messenger-metabolite flux reduction from reduced secretory IgA and other CMD's, immune repression from opportunistic infections and consequent and continuing attenuated measles virus latency, results in an ongoing inability to achieve homeostasis between metabolic functions and immune functions. This manifests as autism. Three tests of this theory are possible. First, treatment with vaccine derived (attenuated) measles N protein specific secretory immunoglobulin A, which is capable of neutralizing the interference. Theoretically, such a test/treatment would restore homeostasis, with a gradual improvement of the autistic condition. Second, it is proposed that if (vaccine derived) attenuated measles N protein specific IgA is properly administered concurrent to infant measles vaccination, few if any cases of autism should be observed, while still providing protection against measles. Third, immunization of the mother with MMR vaccine and subsequent immunization of the child during concurrent breastfeeding. Theoretically, children could then receive sufficient attenuated measles specific secretory IgA via breast milk with few if any cases of autism (or measles) observed. If correct, these tests could provide empirical evidence of an indirect relationship between autism and attenuated measles virus/vaccination.

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      This work has been published open access under Creative Commons Attribution License CC BY 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Conditions, terms of use and publishing policy can be found at www.scienceopen.com.

      Life sciences
      autism research and theory,autism research 2022,autism research,Autism Spectrum Disorder and autism theory,MMR and autism theory,measles and autism,autism theory,autism preprint,autism
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      Review text

      It is a very good work which tackles a difficult subject and which is the subject of contradictory debate in the scientific world. The approach to the subject is interesting since it is based on clinical experience, however the ethical issues leave something to be desired. It is important that the work be better organized, with a standard publication format since it is, until proven otherwise, a literature review. So I suggest to the authors to correct the format of presentations with an introductory section, a methodology section presenting the stages of the realization of the work whether it is the experiment described and the choice of the articles or other documents cited. And, in the body of the text, instead of presenting the sections by discussions 1,2, etc... it is better to present them in the form of sub-sections with of course the sub-titles mentioned in the text. We are at 48 pages, let's say it's excessively long. so it is important to reduce the text to around 4500-5000 words say 15-20 pages at most. One of the missing elements of the work is the illustrations. There are things that can be tabulated like risk factors. Also try to add images to help readers.


      There is no disagreement from the author that this work is excessively long.  However, due to the  controversial

      nature of the topic, it became paramount that all avenues of  discussion be fully addressed.  There were simply

      too many issues that needed a detailed explanation,   A standard  format of average length could not have accomplished

      this. The adding of images and illustrations at the expense of  referenced comments, would also risk a failure to address 

      the critical arguements against the stated theory. This author feels strongly  that  to mount a successful challenge

      to  the strongly held and well entrenched viewpoint that there is no connection  between autism and measles

      vaccine,  a comprehensive,  detailed, well explained,  and highly testable  theory is mandated.  The non-standard format

      of this paper hopefully allows the reader to better understand all the issues involved. 


      2022-12-30 08:34 UTC

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