Average rating: | Rated 4.5 of 5. |
Level of importance: | Rated 4 of 5. |
Level of validity: | Rated 4 of 5. |
Level of completeness: | Rated 4 of 5. |
Level of comprehensibility: | Rated 5 of 5. |
Competing interests: | None |
This article emphasizes the need for further research on (phyto)molecules that could be used for the prevention and treatment of COVID-19. Frist step, provided in this article, is molecular docking. Molecules that are proved to be relevant by moleculart docking methods must be further investigated in preclinical and clinical studies. Authors provided an in silico evidence that phenformin and Docosahexaenoic acid (DHA) are potent ACE2 and IL-6 inhibitors, and it could be used to block the SARS-CoV-2 entry in the human respiratory cells, but more preclinical and clinical research is mandatory. DHA is a potent antioxidant and it could be useful in lowering the risk for cytokine storm. Authors also emphasize the important of cytokine storm in COVID-19 pathophysiology. The more severe cytokine storm is, the more sever is the disease. Cytokine storm is associated with poor clinical outcomes and therefore, the investigation of molecules that could prevent cytokine storm or lower its intensitiy is very important.