+1 Recommend
    • Review: found
    Is Open Access

    Review of '<b>STRA6 (vitamin A receptor), as a Novel binding receptor of COVID-19 </b>'

    <b>STRA6 (vitamin A receptor), as a Novel binding receptor of COVID-19 </b>Crossref
    Interesting, important
    Average rating:
        Rated 4.5 of 5.
    Level of importance:
        Rated 5 of 5.
    Level of validity:
        Rated 4 of 5.
    Level of completeness:
        Rated 4 of 5.
    Level of comprehensibility:
        Rated 4 of 5.
    Competing interests:

    Reviewed article

    • Record: found
    • Abstract: found
    • Article: found
    Is Open Access

    STRA6 (vitamin A receptor), as a Novel binding receptor of COVID-19

    A global pandemic of pneumonia caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began in Wuhan, China, at the end of 2019. Although, the ACE2 receptor has been shown to be the main entry receptor of COVID-19, but here, in our docking analysis , we predicted and discovered a novel receptor called STRA6 that may play a critical role in the pathogenicity of COVID-19 and explain the common pre and post COVID-19 symptoms with uncertain etiology. STRA6 receptor expressed in many organs and immune cells, upregulated by retinoic acid jm6 (STRA6) was the first protein to be identified in a novel category of proteins, cytokine signaling transporters, due to its ability to function as both a cell surface receptor and a membrane protein that binds to retinol binding protein facilitating cellular uptake of retinol. In agreement to our findings, the main ligand of STRA6 (vitamin/retinol) was found to be significantly reduced during COVID-19 infection.

      Review information

      This work has been published open access under Creative Commons Attribution License CC BY 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Conditions, terms of use and publishing policy can be found at www.scienceopen.com.

      retinoic acid receptors,COVID-19,spike proteins,COVID,sars cov2,molecular docking, SARS6
      ScienceOpen disciplines:

      Review text

      This article is important because of the discovery of potentially new SARS-CoV-2 binding site, STRA6 (vitamin A receptor). Other researchers also found that anosmia caused by SARS-CoV-2 might be associated with vitamin A deficiency and this article gives a possible explanation why is that: SARS-CoV-2 binds at STRA6 receptor blocking the natural ligand of STRA6 receptor, which is vitamin A, with consequent lower levels of vitamin A. Some researchers already proposed that nasal drops with vitamin A can be used to restore the sense of smell in patients suffering from COVID-19 induced anosmia or hyposmia. Therefore, systemic and local aplication of vitamin A might be associated with better clinical outcome, but more preclinical and clinical research is mandatory. This article only needs minor corrections, such as minor grammatical errors.


      Comment on this review

      Version and Review History