Review of 'Matrix-bound nanovesicles within ECM bioscaffolds'

Beyond extracellular vesicles (EVs) exisiting in biologic fluids, there are EVs presenting within the extracellular matrix (ECM) of connective tissues. The authors put more attention on the presence and functions of EVs adhesive to or encapsulated within tissue ECM. As a result, EVs provided significant mechanistic inductions on ECM bioscaffold formations and regulation of tissue homeostasis. This imteresting and important investigation can be considered as a guideline to future studies in this area.