Review of 'MicroRNAs : An Emerging Player In Autophagy'

This is very focused and updated review on a topic that is capturing increasing interest in the scientific community. The manuscript is written in a clear and readable manner.

There is only a minor typing error to be corrected at page 4, right column: "metabolic stresses and thereof sensitized sensitizes hepatocellular".

The literature cited covers the most relevant papers, though the authors have failed to cite some review-papers on this same subject. Also, the implications in the biology and therapy of diseases (Conclusion, page 5), and in particular of cancer could be expanded. In this respect, I would recommend the authors to refer to the papers listed below. The readers would appreciate to read more about the role of miRNAs in the cross-talk between apoptosis and autophagy and the implications in cancer development and chemoresistance. I am in favor of the publication of this article provided that the authors address the above issues.

[1] Chen Y, Fu LL, Wen X, Liu B, Huang J, Wang JH, Wei YQ. Oncogenic and tumor suppressive roles of microRNAs in apoptosis and autophagy. Apoptosis. 2014 Aug;19(8):1177-89. doi: 10.1007/s10495-014-0999-7.

[2] Pan B, Yi J, Song H. MicroRNA-mediated autophagic signaling networks and cancer chemoresistance. Cancer Biother Radiopharm. 2013 Oct;28(8):573-8. doi: 10.1089/cbr.2012.1460.

[3] Jing Z, Han W, Sui X, Xie J, Pan H. Interaction of autophagy with microRNAs and their potential therapeutic implications in human cancers. Cancer Lett. 2015 Jan 28;356(2 Pt B):332-8.

[4] Titone R, Morani F, Follo C, Vidoni C, Mezzanzanica D, Isidoro C. Epigenetic control of autophagy by microRNAs in ovarian cancer. Biomed Res Int. 2014;2014:343542. doi: 10.1155/2014/343542.

[5] Liu B, Wen X, Cheng Y. Survival or death: disequilibrating the oncogenic and tumor suppressive autophagy in cancer. Cell Death Dis. 2013 Oct 31;4:e892. doi: 10.1038/cddis.2013.422.