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    Review of 'MicroRNAs : An Emerging Player In Autophagy'

    MicroRNAs : An Emerging Player In AutophagyCrossref
    A very focused and updated review
    Average rating:
        Rated 4.5 of 5.
    Level of importance:
        Rated 5 of 5.
    Level of validity:
        Rated 4 of 5.
    Level of completeness:
        Rated 4 of 5.
    Level of comprehensibility:
        Rated 5 of 5.
    Competing interests:

    Reviewed article

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    • Abstract: found
    • Article: found
    Is Open Access

    MicroRNAs : An Emerging Player In Autophagy

    Autophagy is an evolutionarily conserved self-digestion process for the quality control of intracellular entities in eukaryotes. In the past few years, mounting evidence indicates that microRNAs (miRNAs)-mediated post-transcriptional regulation of gene expression represents an integral part of the autophagy regulatory network and may have a substantial effect on autophagy-related physiological and pathological conditions including cancer. Herein, we examine some of the molecular mechanisms by which microRNAs manipulate the autophagic machinery to maintain cellular homeostasis and their biological outputs during cancer development. A better understanding of interaction between microRNAs and cellular autophagy may ultimately benefit future cancer diagnostic and anticancer therapeutics.

      Review information

      This work has been published open access under Creative Commons Attribution License CC BY 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Conditions, terms of use and publishing policy can be found at www.scienceopen.com.

      Microbiology & Virology
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      Review text

      This is very focused and updated review on a topic that is capturing increasing interest in the scientific community. The manuscript is written in a clear and readable manner.

      There is only a minor typing error to be corrected at page 4, right column: "metabolic stresses and thereof sensitized sensitizes hepatocellular".

      The literature cited covers the most relevant papers, though the authors have failed to cite some review-papers on this same subject. Also, the implications in the biology and therapy of diseases (Conclusion, page 5), and in particular of cancer could be expanded. In this respect, I would recommend the authors to refer to the papers listed below. The readers would appreciate to read more about the role of miRNAs in the cross-talk between apoptosis and autophagy and the implications in cancer development and chemoresistance. I am in favor of the publication of this article provided that the authors address the above issues.

      [1] Chen Y, Fu LL, Wen X, Liu B, Huang J, Wang JH, Wei YQ. Oncogenic and tumor suppressive roles of microRNAs in apoptosis and autophagy. Apoptosis. 2014 Aug;19(8):1177-89. doi: 10.1007/s10495-014-0999-7.

      [2] Pan B, Yi J, Song H. MicroRNA-mediated autophagic signaling networks and cancer chemoresistance. Cancer Biother Radiopharm. 2013 Oct;28(8):573-8. doi: 10.1089/cbr.2012.1460.

      [3] Jing Z, Han W, Sui X, Xie J, Pan H. Interaction of autophagy with microRNAs and their potential therapeutic implications in human cancers. Cancer Lett. 2015 Jan 28;356(2 Pt B):332-8.

      [4] Titone R, Morani F, Follo C, Vidoni C, Mezzanzanica D, Isidoro C. Epigenetic control of autophagy by microRNAs in ovarian cancer. Biomed Res Int. 2014;2014:343542. doi: 10.1155/2014/343542.

      [5] Liu B, Wen X, Cheng Y. Survival or death: disequilibrating the oncogenic and tumor suppressive autophagy in cancer. Cell Death Dis. 2013 Oct 31;4:e892. doi: 10.1038/cddis.2013.422.


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