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Review of 'Apolipoprotein C-III's role in cardiovascular diseases, a short review.'

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A brief review regarding ApoC-III, but need to improve the text and structure.
Average rating:
    Rated 2 of 5.
Level of importance:
    Rated 2 of 5.
Level of validity:
    Rated 2 of 5.
Level of completeness:
    Rated 2 of 5.
Level of comprehensibility:
    Rated 1 of 5.
Competing interests:
None

Reviewed article

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  • Abstract: found
  • Article: found
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Apolipoprotein C-III's role in cardiovascular diseases, a short review.

 Olteanu Emilian (corresponding) (2014)
In this short review we show the important role played by apoC-III in the lipid dysregulation present in the majority of cardiovascular diseases. With emphasis on the mutations present in a minority of individuals that confer protection. With this in mind we state that apoC-III should be considered a valid target for pharmaceutical intervention and cardiovascular disease control and progression.
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    Review information

    10.14293/S2199-1006.1.SOR-MED.AFAFP0.v1.RQGPNG

    This work has been published open access under Creative Commons Attribution License CC BY 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Conditions, terms of use and publishing policy can be found at www.scienceopen.com.

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    Review text

    In the present study the author summarizes the findings concerning ApoC-III in metabolic imbalance and cardiovascular diseases. This paper focus on mutations present in a minority of individuals and suggests that ApoC-III should be considered as a possible target for pharmacological intervention.

    Major Comments

    1- The abstract does not address the importance of apolipoprotein C in cardiovascular and metabolic disease. I suggest that the abstract be improved and/or complement the abstract with the previously stated information.

    2- In the introduction, the sentence “The overall effects of apoC-III modulation in mice models are supported by genetic association studies in various human populations [5]”. Please add more than one reference to justify the use of the pluralized version of the noun, “study”. Alternatively, if it has only one citation, please adjust the plural to the singular.

    3- The introduction does not have a clear objective. Please include the main goal(s) of the study to better guide the reader.

    4- The author discusses the relationships among the genetic factors related to ApoC diseases and concludes that there ought to be a specific potential therapeutic target, and suggests this target. However, there is no strong argumentation that leads to this conclusion in the text. I believe that would be important to describe at least one potential target and add a figure summarizing this pathway.

    Minor Comments;

    In the first paragraph of the topic “function”, the author indicates the concentration of ApoC in human body; however, I suggest that the author checks this value in more current studies.

    I suggest an overall English review of the manuscript. There are many sentence are difficult to understand.

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