Review of 'COVID-19 And Erythrocyte Aggregates: An Intensivists Experience When Being Affected'

The article highlights an important aspect that might be contributing to the pathophysiology and complication process caused by nCOV-19. However, the presentation and writing style needs modification. The abstract appears to be more suitable as an introduction. Case description like age, physical activity, etc., is better noted under the case history. Medication dosage is essential to be mentioned and better presented in sentence format rather than in bullet. ESR data is missing: how the authors concluded about erythrocytes aggregates (increased) need more clarification. Many factors may cause hemoconcentration; even fever can cause it, infective etiologies can cause it [Sloop GD, De Mast Q, Pop G, Weidman JJ, St Cyr JA. The Role of Blood Viscosity in Infectious Diseases. Cureus. 2020;12(2):e7090. Published 2020 Feb 24. doi:10.7759/cureus.7090]. So, it is important to note the trend of ESR, PCV over time. 

Intravenous fluid therapy has an inverse relation with PCV/Hematocrit [Lahsaee SM, Ghaffaripour S, Hejr H. The Effect of Routine Maintenance Intravenous Therapy on Hemoglobin Concentration and Hematocrit during Anesthesia in Adults. Bull Emerg Trauma. 2013;1(3):102‐107.]. Therefore, how negative fluid balance helped in maintaining normal or near-normal hematocrit in a person who already had hemoconcentration requires more explanation. 

The case, however, teaches us important aspects to ponder in such patients and the possible role of iron chelation and supportive therapy.