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    Review of 'Autism Revisited: (expanded 2022 version) <br/>Serendipitous Observations and Theory Relevant To Autism'

    Autism Revisited: (expanded 2022 version) <br/>Serendipitous Observations and Theory Relevant To AutismCrossref
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    Autism Revisited: (expanded 2022 version)
    Serendipitous Observations and Theory Relevant To Autism

    It is hypothesized that the measles N protein component of the attenuated (vaccine derived) measles virus, chronically interfers with a specific homeostatic mechanism that provides balance between metabolic and immune function, resulting in autism. First, congenital metabolic diseases or risk factors, produce primary LOCAL and CONTINUING SUPPRESSIONS of enzymatic and immune functions. Critical among these risk factors is extremely low or non-existent secretory IgA. Second, the overall cellular homeostatic environment is then severely affected by GLOBAL and TRANSIENT metabolic and immune SUPPRESSIONS from the attenuated measles vaccination. Third, the combined effects of severe immune/enzymatic suppressions from the attenuated measles virus, severely reduced IgA, and other CMD's, allows opportunistic infections to flourish, which support secondary immune and enzyme suppressions. Finally, all these suppressions produce a severe intracellular messenger-metabolite flux reduction, which allows the attenuated measles N protein freedom to interact, and interfere with, the eukaryotic initiation factor eIF3P40. eIF3P40 is joined to the eukaryotic initiation factor eIF4E through an eIF4G linkage. Theoretically, this would create a severe dysregulation in the eukaryotic initiation factor eIF4E, which has been observed in autistic children, and associated with autistic behavior in animal studies. This severe messenger-metabolite flux reduction from reduced secretory IgA and other CMD's, immune repression from opportunistic infections and consequent and continuing attenuated measles virus latency, results in an ongoing inability to achieve homeostasis between metabolic functions and immune functions. This manifests as autism. Three tests of this theory are possible. First, treatment with vaccine derived (attenuated) measles N protein specific secretory immunoglobulin A, which is capable of neutralizing the interference. Theoretically, such a test/treatment would restore homeostasis, with a gradual improvement of the autistic condition. Second, it is proposed that if (vaccine derived) attenuated measles N protein specific IgA is properly administered concurrent to infant measles vaccination, few if any cases of autism should be observed, while still providing protection against measles. Third, immunization of the mother with MMR vaccine and subsequent immunization of the child during concurrent breastfeeding. Theoretically, children could then receive sufficient attenuated measles specific secretory IgA via breast milk with few if any cases of autism (or measles) observed. If correct, these tests could provide empirical evidence of an indirect relationship between autism and attenuated measles virus/vaccination.

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      Life sciences
      autism research and theory,autism research 2022,autism research,Autism Spectrum Disorder and autism theory,MMR and autism theory,measles and autism,autism theory,autism preprint,autism
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      Review text

      This article started with clinical cases of child's Autism,  and introduced in detail the autism and attenuated measures virus/vacuum, this is a good research topic.

      But there are some problems need to pay attention or need to revise:

      1. Usually the articles have strict writing format including abstract, introduction, materials and methods, results and discussion, and the order cannot be changed;

      2. The abstract of the article is a summary of the full text. Please further refine the abstract of the article;

      3.  In the Experimental Observations section, Please provide more details to ensure the readability and repeatability of the article;

      4. Please ensure that the language in the discussion section is highly concise and make the article is more readable;

      5. Please note the format of references.



      Normally I would strongly support and agree with applying a strict writing format.  The format for this paper

      was chosen not in error or to  defy traditional  presentation.  It was chosen rationally as a compromise between 

      the standard format, and the need to directly confront the  arguements against a theoretical relationship beween

      autism and the measles vaccine. This was no easy task.  The Experimental Observations section  led not to one or

      two discussion sections  but  multiple and varied topic Discussion Sections.  Each  Discusion Section, derived from

      Experimental Observations,  addressed a different aspect of the overall theory.  Each one also  directly addressed

      one or more of the arguements against the theory.  My goal was not to  explain theoretically, one aspect of the

      disease based on clinical observation,  but the entire disease process,  its prevention, and treatment. This goal

      could not be accomplished using strict standard format.  The Abstract Section  also reflected on  this compromise.  

      Efforts were made to limit its scope to the fundamentals of the theory and three  practical tests of the theory.

      References to the Experimental and History Sections were not included in the Abstract Section. Thus it was not

      a true summary of the entire text. 


      In terms of readability, effort was made to explain and define all terms with  attached references.  Conclusions

      and theory were also highly referenced.  It should be noted  here, that  the level of readability  was  directed at

      the  scientific community of both non-autism experts as well as autism experts. This presented a writing

      challenge as well.







      2023-03-03 08:00 UTC

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