Average rating: | Rated 5 of 5. |
Level of importance: | Rated 5 of 5. |
Level of validity: | Rated 5 of 5. |
Level of completeness: | Rated 5 of 5. |
Level of comprehensibility: | Rated 5 of 5. |
Competing interests: | None |
The authors studied the reactions of isosorbide, isomannide and isoidide, with dimethyl carbonate under various conditions. As a whole, this manuscript is well written. The manuscript would benefit from improved a consideration of the following points. First, in the experiment concerning Carboxymethylation reaction of isosorbide and its epimers, the temperature was maintained at 90 °C with a reflux. However, the reaction temperature must be lower than the set temperature due to the production of MeOH. It is recommended that authors determine the temperature of the reactants directly. Furthermore, if authors add some curves along with the change of time, the paper would most certainly be more informative. Secondly, for all reactions, the authors used excessively high DMC, is this really needed?! Removal of DMC consumes energy. It would be appreciated if authors could provide the effect of the molar ratio of DMC: isosorbide and its epimers.