Subcutaneous and Intranasal Administration of 1-Deamino-8- d -Arginine Vasopressin in the Assessment of Renal Concentration Capacity

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Abstract

Maximum urine concentration capacity was studied in healthy adults using different routes and doses of administration of 1-deamino-8- d-arginine vasopressin (DDAVP) – desmopressin. Plasma levels of DDAVP showed a dose-dependent increase after the subcutaneous but not after the intranasal administration. The effect on urine osmolality was similar but more prolonged after the subcutaneous as compared to the intranasal route. We conclude that subcutaneous injection is a simple and reliable way of administering DDAVP. A dose of 4 μg in adults is optimum diagnostically and it corresponds to 20–40 μg administered intranasally.

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Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Publisher: S. Karger AG

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 1987

Publication date (Print): 1987

Publication date (Electronic): 05 December 2008

Volume: 45

Issue: 1

Pages: 27-30

Affiliations

Department of Clinical Chemistry, Central Hospital, Kristianstad; Division of Nephrology, Department of Medicine, General Hospital, Malmö; Biomedicum, University of Uppsala, and Department of Zoophysiology, University of Lund, Sweden

Article

Publisher ID: 184066 Other ID: Nephron 1987;45:27–30

DOI: 10.1159/000184066

PubMed ID: 3808145

SO-VID: 0796746d-4d04-461d-aff1-7d899a4ec37e

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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

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Subcutaneous and Intranasal Administration of 1-Deamino-8- d-Arginine Vasopressin in the Assessment of Renal Concentration Capacity

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Karger: Nephrology

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