A 55-year-old woman presented with conjunctival congestion, retro-orbital pain, and
diplopia. She had received her first vaccine against SARS-CoV-2—ChAdOx1 nCoV-19—10
days before admission. Both on the night after the vaccination and 7 days later, the
patient reported marked flu-like symptoms and a fever. She had no medical history
of visual problems, autoimmune disorders, stroke, thrombosis, thrombocytopenia, neurological
disorders, or arterial disease risk factors—including hypertension, diabetes, or smoking.
On examination, she had binocular diplopia at vertical and right lateral gaze, and
her visual acuity was 0·85 in both eyes. MRI showed superior ophthalmic vein thrombosis
(SOVT) with no contrast filling (figure
) and bilateral high T2 signal intensity of the superior ophthalmic vein (figure).
Figure
SOVT and ischaemic stroke after ChAdOx1 nCoV-19 vaccination
MRI shows SOVT with no contrast filling (arrows; A) and bilateral high T2 signal intensity
of the superior ophthalmic vein (arrows; B). MRI shows an ischaemic stroke in the
left parietal lobe, MCA territory, with restricted diffusion (C). Diagram shows the
timeline of symptoms, MRI findings, dexamethasone treatment, and platelet count (D).
FLS=flu-like symptoms. HP=hemiparesis. SOVT=superior ophthalmic vein thrombosis. MCA=middle
cerebral artery.
Laboratory investigations on admission showed a marked isolated thrombocytopenia of
30 × 109 per L (figure). IgG antiplatelet antibodies were positive, and IgM antiplatelet
antibodies were borderline; a platelet suspension immunofluorescence test and a monoclonal
antibody-specific immobilisation of platelet antigens assay were positive—supporting
a diagnosis of secondary immune thrombocytopenia (ITP). IgG antibodies against platelet
factor 4/polyanion complexes—tested using a lateral flow immunoassay, 4 days after
starting heparinisation—were negative. Other possible causes of thrombocytopenia—including
antiphospholipid syndrome, thrombotic microangiopathy, and hepatitis B virus and hepatitis
C virus, HIV, cytomegalovirus, hantaviruses, and Helicobacter pylori infections—were
excluded.
Because we suspected ITP, intravenous dexamethasone 40 mg daily was given for 4 days
which resulted in an increasing platelet count (figure). Despite the therapeutic heparinisation,
8 days after admission, the patient developed a transient, mild, right-sided hemiparesis,
and aphasia. An MRI showed an ischaemic stroke in the left parietal lobe, middle cerebral
artery territory, with restricted diffusion (figure), which had not been detected
in the earlier scan. The patient then developed right-sided focal seizures which were
controlled with levetiracetam and lacosamide; anticoagulation was switched to phenprocoumon,
and 26 days after admission, she was allowed home.
That 8, 10, and 18 days after the ChAdOx1 nCoV-19 vaccination, our previously healthy
patient developed marked flu-like symptoms, two rare disorders—namely, bilateral SOVT
and ITP, and an ischaemic stroke, may indicate a causal relationship. According to
the European Medicines Agency review, March 18, health-care professionals should be
on the alert for possible cases of thromboembolism—like cerebral venous sinus thrombosis,
pulmonary embolus, and deep vein thrombosis—occurring in people who have recently
received the ChAdOx1 nCoV-19 vaccine. The thrombotic events—including bilateral SOVT
as seen in our patient—may occur in the context of thrombocytopenia (video).
Declaration of interests
We declare no competing interests.