Contributors
Philipp Kirchner: Role: ConceptualizationRole: Formal analysisRole: SoftwareRole: Writing – original
draft
Mathieu Bourdenx:
ORCID: http://orcid.org/0000-0002-9799-9222
Role: ConceptualizationRole: Formal analysisRole: SoftwareRole: Writing – original
draft
Julio Madrigal-Matute:
ORCID: http://orcid.org/0000-0002-0894-5450
Role: ConceptualizationRole: Formal analysisRole: Writing – original draft
Simoni Tiano: Role: InvestigationRole: Validation
Antonio Diaz: Role: InvestigationRole: Validation
Boris A. Bartholdy:
ORCID: http://orcid.org/0000-0002-7401-8591
Role: Data curationRole: SoftwareRole: Writing – review & editing
Britta Will: Role: ConceptualizationRole: Writing – review & editing
Ana Maria Cuervo:
ORCID: http://orcid.org/0000-0002-0771-700X
Role: ConceptualizationRole: SupervisionRole: Writing – review & editing
Anne Simonsen: Role: Academic Editor
Journal
Journal ID (nlm-ta): PLoS Biol
Journal ID (iso-abbrev): PLoS Biol
Journal ID (publisher-id): plos
Journal ID (pmc): plosbiol
Title:
PLoS Biology
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Print):
1544-9173
ISSN
(Electronic):
1545-7885
Publication date
(Electronic):
31
May
2019
Publication date Collection:
May
2019
Publication date PMC-release: 31
May
2019
Volume: 17
Issue: 5
Electronic Location Identifier: e3000301
Affiliations
[1
]
Department of Developmental and Molecular Biology, Albert Einstein College of Medicine,
Bronx, New York, United States of America
[2
]
Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, New York,
United States of America
[3
]
Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York,
United States of America
[4
]
Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, United
States of America
Institute of Basic Medical Sciences, NORWAY
Author notes
The authors have declared that no competing interests exist based on the content of
the submitted manuscript.
[¤]
Current address: Institute of Human Genetics, University Hospital Erlangen, Friedrich-Alexander-Universitaet
Erlangen-Nuernberg, Erlangen, Germany
Author information
Article
Publisher ID:
PBIOLOGY-D-18-00786
DOI: 10.1371/journal.pbio.3000301
PMC ID: 6561683
PubMed ID: 31150375
SO-VID: 13e0e1c2-20f2-4df8-8d3e-5eca7ba4cc4b
Copyright © © 2019 Kirchner et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
History
Date
received
: 25
September
2018
Date
accepted
: 15
May
2019
Page count
Figures: 5,
Tables: 0,
Pages: 27
Funding
Funded by: funder-id http://dx.doi.org/10.13039/100000049, National Institute on Aging;
Award ID: AG031782
Award Recipient
:
ORCID: http://orcid.org/0000-0002-0771-700X
Ana Maria Cuervo
Funded by: funder-id http://dx.doi.org/10.13039/100000049, National Institute on Aging;
Award ID: AG021904
Award Recipient
:
ORCID: http://orcid.org/0000-0002-0771-700X
Ana Maria Cuervo
Funded by: funder-id http://dx.doi.org/10.13039/100000049, National Institute on Aging;
Award ID: AG038072
Award Recipient
:
ORCID: http://orcid.org/0000-0002-0771-700X
Ana Maria Cuervo
Funded by: funder-id http://dx.doi.org/10.13039/100000062, National Institute of Diabetes and Digestive and Kidney Diseases;
Award ID: DK098408
Award Recipient
:
ORCID: http://orcid.org/0000-0002-0771-700X
Ana Maria Cuervo
Funded by: funder-id http://dx.doi.org/10.13039/100007457, JPB Foundation;
Award ID: Cuervo 1
Award Recipient
:
ORCID: http://orcid.org/0000-0002-0771-700X
Ana Maria Cuervo
Funded by: funder-id http://dx.doi.org/10.13039/501100001674, Fondation Leducq;
Award ID: RA15CVD04
Award Recipient
:
ORCID: http://orcid.org/0000-0002-0771-700X
Ana Maria Cuervo
Funded by: funder-id http://dx.doi.org/10.13039/100000968, American Heart Association;
Award ID: 17POST33650088
Award Recipient
:
ORCID: http://orcid.org/0000-0002-0894-5450
Julio Madrigal-Matute
Funded by: Deutsche Forschungemeinschaft
Award ID: KI 1992/1-1
Award Recipient
:
Philipp Kirchner
This work was supported by grants from the National Institutes of Health AG031782,
AG021904, AG038072, DK098408 (to AMC) and the generous support of the JPB Foundation,
Rainwaters Foundation, Leducq Foundation, and Robert and Renée Belfer (to AMC). PK
was supported by a DFG KI 1992/1-1 postdoctoral fellowship; JM-M is supported by postdoctoral
fellowship 17POST33650088 from the American Heart Association and is a Leducq fellow
of the Transatlantic Network of Excellence (RA15CVD04 award). The funders had no role
in study design, data collection and analysis, decision to publish, or preparation
of the manuscript.
Categories
Subject:
Methods and Resources
Subject:
Research and Analysis Methods
Subject:
Database and Informatics Methods
Subject:
Bioinformatics
Subject:
Sequence Analysis
Subject:
Sequence Motif Analysis
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Proteins
Subject:
Post-Translational Modification
Subject:
Phosphorylation
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Proteins
Subject:
Proteomes
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Structures and Organelles
Subject:
Lysosomes
Subject:
Biology and Life Sciences
Subject:
Molecular Biology
Subject:
Molecular Biology Techniques
Subject:
Molecular Biology Assays and Analysis Techniques
Subject:
Amino Acid Analysis
Subject:
Research and Analysis Methods
Subject:
Molecular Biology Techniques
Subject:
Molecular Biology Assays and Analysis Techniques
Subject:
Amino Acid Analysis
Subject:
Biology and Life Sciences
Subject:
Computational Biology
Subject:
Genome Analysis
Subject:
Gene Ontologies
Subject:
Biology and Life Sciences
Subject:
Genetics
Subject:
Genomics
Subject:
Genome Analysis
Subject:
Gene Ontologies
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cell Processes
Subject:
Cell Death
Subject:
Autophagic Cell Death
Subject:
Physical Sciences
Subject:
Chemistry
Subject:
Chemical Compounds
Subject:
Organic Compounds
Subject:
Amino Acids
Subject:
Acidic Amino Acids
Subject:
Glutamine
Subject:
Physical Sciences
Subject:
Chemistry
Subject:
Organic Chemistry
Subject:
Organic Compounds
Subject:
Amino Acids
Subject:
Acidic Amino Acids
Subject:
Glutamine
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Proteins
Subject:
Amino Acids
Subject:
Acidic Amino Acids
Subject:
Glutamine
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