Malancha Karmakar:
ORCID: http://orcid.org/0000-0003-0303-2895
Role: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
ValidationRole: Writing – original draft
Carlos H. M. Rodrigues:
ORCID: http://orcid.org/0000-0002-4420-6401
Role: SoftwareRole: Writing – original draft
Kathryn E. Holt:
ORCID: http://orcid.org/0000-0003-3949-2471
Role: Data curationRole: Formal analysisRole: ResourcesRole: ValidationRole: Writing
– review & editing
Sarah J. Dunstan:
ORCID: http://orcid.org/0000-0001-7873-933X
Role: Data curationRole: Formal analysisRole: ValidationRole: Writing – review & editing
Justin Denholm: Role: ConceptualizationRole: Formal analysisRole: ValidationRole: Writing – review
& editing
David B. Ascher: Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Funding acquisitionRole:
InvestigationRole: MethodologyRole: Project administrationRole: SupervisionRole: ValidationRole:
Writing – review & editing
Igor Mokrousov: Role: Editor
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
29
May
2019
Publication date Collection: 2019
Volume: 14
Issue: 5
Electronic Location Identifier: e0217169
Affiliations
[1
]
Victorian Tuberculosis Program, Melbourne Health, Victoria, Australia
[2
]
Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne,
Victoria, Australia
[3
]
Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria,
Australia
[4
]
Structural Biology and Bioinformatics, Baker Heart and Diabetes Institute, Melbourne,
Victoria, Australia
[5
]
The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Victoria,
Australia
[6
]
Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom
St Petersburg Pasteur Institute, RUSSIAN FEDERATION
Author notes
Competing Interests: The authors have declared that no competing interests exist.
Author information
Article
Publisher ID:
PONE-D-19-03087
DOI: 10.1371/journal.pone.0217169
PMC ID: 6541270
PubMed ID: 31141524
SO-VID: 1e1e45a5-72e5-4e3d-a9c4-0049b44e99ab
Copyright © © 2019 Karmakar et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
Funded by: funder-id http://dx.doi.org/10.13039/501100000265, Medical Research Council;
Award ID: MR/M026302/1
Award Recipient
:
David B. Ascher
Funded by: funder-id http://dx.doi.org/10.13039/501100000925, National Health and Medical Research Council;
Award ID: APP1072476
Award Recipient
:
David B. Ascher
Funded by: funder-id http://dx.doi.org/10.13039/501100000925, National Health and Medical Research Council;
Award ID: APP1056689
Award Recipient
:
ORCID: http://orcid.org/0000-0003-3949-2471
Kathryn E. Holt
Funded by: funder-id http://dx.doi.org/10.13039/100012698, Jack Brockhoff Foundation;
Award ID: JBF 4186, 2016
Award Recipient
:
David B. Ascher
M.K was funded by the Melbourne Research Scholarship. D.B.A was funded by a Newton
Fund RCUK-CONFAP Grant awarded by The Medical Research Council (MRC) and Fundação
de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG) (MR/M026302/1), the Jack
Brockhoff Foundation (JBF 4186, 2016), and a C. J. Martin Research Fellowship from
the National Health and Medical Research Council (NHMRC) of Australia (APP1072476).
The Vietnam genomic dataset was funded by a NHMRC Australia grant (APP1056689) to
SJD and KEH. This work was supported in part by the Victorian Government's OIS Program.
No funding bodies had any role in study design, data collection and analysis, decision
to publish, or preparation of the manuscript.
Subject:
Research Article
Subject:
Biology and Life Sciences
Subject:
Genetics
Subject:
Mutation
Subject:
Point Mutation
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Bacteria
Subject:
Actinobacteria
Subject:
Mycobacterium Tuberculosis
Subject:
Physical Sciences
Subject:
Physics
Subject:
Condensed Matter Physics
Subject:
Solid State Physics
Subject:
Crystallography
Subject:
Crystal Structure
Subject:
Biology and Life Sciences
Subject:
Genetics
Subject:
Gene Identification and Analysis
Subject:
Mutation Detection
Subject:
Biology and Life Sciences
Subject:
Computational Biology
Subject:
Genome Analysis
Subject:
Biology and Life Sciences
Subject:
Genetics
Subject:
Genomics
Subject:
Genome Analysis
Subject:
Physical Sciences
Subject:
Mathematics
Subject:
Applied Mathematics
Subject:
Algorithms
Subject:
Machine Learning Algorithms
Subject:
Research and Analysis Methods
Subject:
Simulation and Modeling
Subject:
Algorithms
Subject:
Machine Learning Algorithms
Subject:
Computer and Information Sciences
Subject:
Artificial Intelligence
Subject:
Machine Learning
Subject:
Machine Learning Algorithms
Subject:
Biology and Life Sciences
Subject:
Molecular Biology
Subject:
Macromolecular Structure Analysis
Subject:
Protein Structure
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Proteins
Subject:
Protein Structure
Subject:
Medicine and Health Sciences
Subject:
Infectious Diseases
Subject:
Bacterial Diseases
Subject:
Tuberculosis
Subject:
Medicine and Health Sciences
Subject:
Tropical Diseases
Subject:
Tuberculosis