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Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers.
Hisayuki Shigematsu
1 ,
Li Lin ,
Takao Takahashi ,
Masaharu Nomura ,
Makoto Suzuki ,
Ignacio I Wistuba ,
Kwun M Fong ,
Huei Lee ,
Shinichi Toyooka ,
Nobuyoshi Shimizu ,
Takehiko Fujisawa ,
Ziding Feng ,
Jack A Roth ,
Joachim Herz ,
John D Minna ,
Adi F Gazdar
Mar 02 2005
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Abstract
Mutations in the tyrosine kinase (TK) domain of the epidermal growth factor receptor (EGFR) gene in lung cancers are associated with increased sensitivity of these cancers to drugs that inhibit EGFR kinase activity. However, the role of such mutations in the pathogenesis of lung cancers is unclear.