Analysis of Blood Spot 17α-Hydroxyprogesterone Concentration in Neonates

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Abstract

Blood spot 17α-hydroxyprogesterone (17-OHP) concentrations were measured in 515 infants aged from the 4th to the 81 st day of life, using a fluorescence enzyme immunoassay method, and the values obtained were analyzed with respect to birth weight, gestational age at birth and sampling age, to obtain accurate reference ranges and to decide appropriate cut-off limits in a neonatal mass screening for steroid 21 -hydroxylase deficiency. The results obtained indicate that the blood spot 17-OHP values in neonates should be interpreted using several different reference ranges obtained on the basis of the equivalent age of gestation at blood sampling. In the mass screening, therefore, the cut-off limits for recall are decided by these reference ranges as follows: (1) for blood resampling, 120, 30 and 25 nmol/l for the equivalent sampling ages of 31 weeks or less, 32–41 weeks and 42 weeks or more, respectively, and (2) for rapid confirmation of the disease by means of physical and laboratory examinations, 210, 60 and 60 nmol/l, respectively.

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Journal

Journal ID (publisher-id): HRE

Journal ID (nlm-ta): Horm Res Paediatr

Journal ID (doi): 10.1159/issn.1663-2818

Title: Hormone Research in Paediatrics

Publisher: S. Karger AG

ISSN (Print): 1663-2818

ISSN (Electronic): 1663-2826

Publication date Subscription-year: 1988

Publication date (Print): 1988

Publication date (Electronic): 02 December 2008

Volume: 30

Issue: 6

Pages: 246-251

Affiliations

^aDepartment of Pediatrics, Faculty of Medicine, Tokyo Medical and Dental University; ^bTokyo Branch of the Association of Health Service; ^cTokyo Branch of the Japan Association for Maternal Welfare; ^dDepartment of Pediatrics, Second Hospital, Tokyo Women’s Medical College; ^eDepartment of Pediatrics, Tokyo Metropolitan Kiyose Children’s Hospital; ^fDepartment of Pediatrics, School of Medicine, Nihon University, Tokyo, Japan

Article

Publisher ID: 181071 Other ID: Horm Res 1988;30:246–251

DOI: 10.1159/000181071

PubMed ID: 3266938

SO-VID: 2c8d80c1-c467-4ad5-8b21-64b0c240397a

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 07 March 1988

Date accepted : 26 July 1988

Page count

Pages: 6

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