Hydroxyethyl starch (HES) is used for repletion of acute intravasal volume loss in surgical patients. However, in critically ill patients, HES is associated with acute kidney injury. We aimed to evaluate the effect of HES on perioperative cystatin C (cystC)-derived estimated glomerular filtration rates (eGFR cystC) in patients undergoing open and robot-assisted radical prostatectomy.
In this retrospective study we included 179 patients who underwent general anaesthesia for radical prostatectomy received HES perioperatively, and had complete cystC and fluid therapy data available. CystC and corresponding eGFR cystC at postoperative days 1, 3, and 5 were compared with preoperative baseline using Wilcox rank-sum test.
In 179 eligible patients, 6 % HES 130/0.4 was administered in a median (25th to 75th percentile) dose of 1000 mL (1000 to 1000 mL). Baseline eGFR cystC was 109.4 mL/min (100.3 to 118.7 mL/min). eGFR cystC on postoperative days 1, 3, and 5 was 120.4 mL/min (109.4 to 134.0 mL/min), 120.4 mL/min (109.4 to 132.9 mL/min), and 117.9 mL/min (106.6 to 129.8 mL/min), respectively ( p < 0.001 compared with baseline, each). No patient had an eGFR cystC-decrease of ≥25 % from baseline.