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      17beta-estradiol and ICI-182780 regulate the hair follicle cycle in mice through an estrogen receptor-alpha pathway.

      American Journal of Physiology - Endocrinology and Metabolism
      Administration, Topical, Animals, Blotting, Northern, Dose-Response Relationship, Drug, Estradiol, administration & dosage, analogs & derivatives, pharmacology, Estrogen Antagonists, Estrogen Receptor alpha, Female, Hair, growth & development, Hair Follicle, drug effects, physiology, Immunohistochemistry, Mice, Ovariectomy, RNA, Messenger, analysis, Receptors, Estrogen, genetics, Skin, metabolism

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          Abstract

          Estradiol (E(2)) applied topically twice weekly to mouse skin at doses as low as 1 nmol inhibited hair growth by blocking the transition of the hair follicle from the resting phase (telogen) to the growth phase (anagen). In contrast, application of

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