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      The comparison of ultrasound and non-contrast helical computerized tomography for children nephrolithiasis detection

      research-article
      Urology Annals
      Medknow Publications & Media Pvt Ltd
      Children, helical computerized tomography, imaging, nephrolithiasis

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          Abstract

          Aims:

          Nephrolithiasis is less common in children than adults, but its diagnosis and management in children may be more perplexing. In this article, we compare two imaging ultrasound (US) and non-contrast helical computerized tomography (CT) for diagnosis of nephrolithiasis.

          Subjects and Methods:

          A total of 20 children who diagnosed as nephrolithiasis by US were imaged simultaneously by non-contrast helical CT. Their history like as family history in first and second degree relatives and urine analysis for hematuria and urine randomly calcium to creatinine ratio was obtained. All data analyzed by χ 2 and Mann-Whitney U-test in SPSS 16 and P < 0.05 was considered to be significant.

          Results:

          Out of 20 cases, only 5 cases diagnosed as nephrlithiasis by US were confirmed by CT method 2 out of 20 cases had another extrarenal origin for their complaint who diagnosed wrongly as nephrolithiasis by US. Stone size based of US that was confirmed by CT method was larger 4.6 ± 1.5 (minimum 3 max 6 mm) than non-confirmed ones 2.3 ± 0.7 mm ( P 0.002). Hematuria occurred more in correct diagnosed compared with misdiagnosed ( P 0.005). Positive family history and urine calcium ratio was not differed between two groups.

          Conclusions:

          Non contrast helical CT is essential to confirm of nephrolithiasis and other extrarenal origin of complaints, which diagnosed wrongly as nephrolithiasis in children. Stone size and presence of hematuria are two major factors for right diagnosis of nephrolithiasis as US method but Urine calcium excretion ratio or positive family history cannot be predictive as this study.

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          Most cited references41

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          Acute flank pain: comparison of non-contrast-enhanced CT and intravenous urography.

          To compare non-contrast-enhanced computed tomography (CT) and intravenous urography (IVU) in the evaluation of patients who present with acute flank pain and in whom ureteric obstruction is suspected. The findings at non-contrast-enhanced CT and IVU in 20 patients with acute flank pain were compared for the presence or absence of ureteric obstruction and delineation of ureteric stones. Twelve of the 20 patients had non-contrast-enhanced CT and IVU findings consistent with ureteric obstruction. Of these 12 patients, five had a ureteric stone that was demonstrated on both non-contrast-enhanced CT scans and IVU radiographs, six had a stone that was depicted on non-contrast-enhanced CT scans only, and in one patient a stone could not be delineated definitively on either non-contrast-enhanced CT scans or IVU radiographs. Eight patients had findings at non-contrast-enhanced CT and IVU consistent with the absence of obstruction. Non-contrast-enhanced CT is more effective than IVU in precisely identifying ureteric stones and is equally effective as IVU in the determination of the presence or absence of ureteric obstruction.
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            Diagnosis of acute flank pain: value of unenhanced helical CT.

            The purpose of our study was to determine the value of unenhanced CT in the diagnosis of acute flank pain. We determined the accuracy of unenhanced Ct for stone detection as well as the detection of abnormalities unrelated to stone disease. During an 18-month interval, 292 patients with acute flank pain were imaged with unenhanced CT. Confirmation of the CT diagnosis was obtained for 210 patients: One hundred patients were proved to have ureteral stones based on other imaging studies (58 patients), lithotripsy (seven patients), ureteroscopic stone extraction (five patients), and stone recovery (30 patients). One hundred ten patients were proved not to have ureteral stones based on other imaging studies (24 patients), failure to recover a stone (56 patients), or a confirmed diagnosis unrelated to stone disease (30 patients). This latter group of 30 patients included diagnoses of adnexal masses (eight patients), appendicitis (five patients), diverticulitis (four patients), and common bile duct stones (three patients), as well as other diagnoses. Unenhanced CT findings were falsely negative for stone disease in three patients and falsely positive for stone disease in four patients. These data yield a sensitivity of 97%, a specificity of 96%, and an accuracy of 97% for diagnosing ureteral stone disease. Of 31 patients with a CT abnormality unrelated to stone disease, there was one false-negative diagnosis of acute appendicitis. Unenhanced CT is a valuable technique for examining patients with acute flank pain in whom a clinical diagnosis is uncertain. It can accurately determine the presence or absence of ureteral stones as well as extraurinary causes of acute flank pain. In most cases, other imaging studies are not required.
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              Diagnostic examination of the child with urolithiasis or nephrocalcinosis

              Urolithiasis and nephrocalcinosis are more frequent in children then currently anticipated, but still remain under- or misdiagnosed in a significant proportion of patients, since symptoms and signs may be subtle or misleading. All children with colicky abdominal pain or macroscopic hematuria should be examined thoroughly for urolithiasis. Also, other, more general, abdominal manifestations can be the first symptoms of renal stones. The patients and their family histories, as well as physical examination, are important initial steps for diagnostic evaluation. Thereafter, diagnostic imaging should be aimed at the location of calculi but also at identification of urinary tract anomalies or acute obstruction due to stone disease. This can often be accomplished by ultrasound examination alone, but sometimes radiological methods such as plain abdominal films or more sensitive non-enhanced computed tomography are necessary. Since metabolic causes are frequent in children, diagnostic evaluation should be meticulous so that metabolic disorders that cause recurrent urolithiasis or even renal failure, such as the primary hyperoxalurias and others, can be ruled out. The stone is not the disease itself; it is only one serious sign! Therefore, thorough and early diagnostic examination is mandatory for every infant and child with the first stone event, or with nephrocalcinosis.
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                Author and article information

                Journal
                Urol Ann
                Urol Ann
                UA
                Urology Annals
                Medknow Publications & Media Pvt Ltd (India )
                0974-7796
                0974-7834
                Oct-Dec 2014
                : 6
                : 4
                : 309-313
                Affiliations
                [1]Dr. Mohammad Mosadegh Clinic, Tehran, Iran
                Author notes
                Address for correspondence: Dr. Majid Malaki, Pediatric Nephrologist, Dr. Mohammad Mosadegh Clinic, Tehran, Iran. E-mail: madjidmalaki@ 123456gmail.com
                Article
                UA-6-309
                10.4103/0974-7796.140991
                4216536
                5a7ff6cc-e6d0-47cc-b0d9-e7cf8c19df87
                Copyright: © Urology Annals

                This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 08 August 2013
                : 11 November 2013
                Categories
                Original Article

                Urology
                children,helical computerized tomography,imaging,nephrolithiasis
                Urology
                children, helical computerized tomography, imaging, nephrolithiasis

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