Rationale and Application of Beta-2-Microglobulin Measurements to Detect Acute Transplant Rejection

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Abstract

Serum and urinary concentrations of β2-microglobulin were measured for the first 21 days after renal transplantation to aid in diagnosis of acute rejection. Criteria developed after study of 15 patients were applied to the entire group of 31 consecutive cases. 29 instances meeting our criteria were identified in 651 days at risk and were associated with a mean maximal increase of serum creatinine of 74.8%. β2-Microglobulin methods may make possible detection of what is now subclinical rejection. β2-Microglobulin methods, however, are an adjunct to, not a replacement for classical methods for detecting acute rejection.

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Journal

Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Publisher: S. Karger AG

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 1981

Publication date (Print): 1981

Publication date (Electronic): 02 December 2008

Volume: 27

Issue: 4-5

Pages: 260-264

Affiliations

Section of Nephrology/Hypertension, Department of Medicine and Division of Transplantation, Department of Surgery, Northwestern University Medical School, Chicago, Ill., USA

Article

Publisher ID: 182064 Other ID: Nephron 1981;27:260–264

DOI: 10.1159/000182064

PubMed ID: 6167873

SO-VID: 64374031-7d44-4686-abb2-efb0b3312bb9

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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

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Pages: 5

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