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Abstract
Calcified aortic valve disease (CAVD) is a prevalent condition, affecting 25% of people
older than 65 years. CAVD and atherosclerosis share common risk factors and pathogenic
mechanisms. Nevertheless, they present different pathologic lesions. The main factors
involved in the pathogenesis of CAVD are genetic predisposition, the process of valvular
calcification, deposition of lipoproteins, and chronic inflammation. Studies have
suggested a potential benefit from early treatment with angiotensin converting enzyme
inhibitors or angiotensin-II receptor blockers, and particularly with statins. Observational
studies on risk factors for the CAVD, and randomized clinical trials on primary and
secondary prevention in subjects with high risk for the disease, would be necessary
to improve the clinical management of CAVD.