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Reduction of cortical oxygenation in chronic kidney disease: evidence obtained with a new analysis method of blood oxygenation level-dependent magnetic resonance imaging.
Bastien Milani
1
,
2 ,
Annalisa Ansaloni
1 ,
Sofia Sousa-Guimaraes
1 ,
Nima Vakilzadeh
1 ,
Maciej Piskunowicz
3 ,
Bruno Vogt
4 ,
Matthias Stuber
2
,
5 ,
Michel Burnier
1 ,
Menno Pruijm
1
Oct 17 2016
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Abstract
Determinations of renal oxygenation by blood oxygenation level-dependent magnetic resonance imaging (BOLD-MRI) in chronic kidney disease (CKD) patients have given heterogeneous results, possibly due to the lack of a reproducible method to analyse BOLD-MRI. It therefore remains uncertain whether patients with CKD have a reduced renal tissue oxygenation. We developed a new method to analyse BOLD-MRI signals and applied it to CKD patients and controls.