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Abstract
In this issue of Cell Reports, Van den Bossche et al. (2016) reveal that, once the
M1 macrophage forms, the accompanying metabolic alterations in the mitochondria are
irreversible, preventing differentiation into the more homeostatic M2 macrophage.
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School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity
College Dublin 2, Ireland. Electronic address: laoneill@tcd.ie.