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      A Comprehensive Survey of Recent Advancements in Molecular Communication

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          A logic-gated nanorobot for targeted transport of molecular payloads.

          Shawn M. Douglas, Ido Bachelet, George M. Church (2012)
          We describe an autonomous DNA nanorobot capable of transporting molecular payloads to cells, sensing cell surface inputs for conditional, triggered activation, and reconfiguring its structure for payload delivery. The device can be loaded with a variety of materials in a highly organized fashion and is controlled by an aptamer-encoded logic gate, enabling it to respond to a wide array of cues. We implemented several different logical AND gates and demonstrate their efficacy in selective regulation of nanorobot function. As a proof of principle, nanorobots loaded with combinations of antibody fragments were used in two different types of cell-signaling stimulation in tissue culture. Our prototype could inspire new designs with different selectivities and biologically active payloads for cell-targeting tasks.
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            Microfluidic diagnostic technologies for global public health.

            Paul Yager, Thayne L Edwards, Elain Fu … (2006)
            The developing world does not have access to many of the best medical diagnostic technologies; they were designed for air-conditioned laboratories, refrigerated storage of chemicals, a constant supply of calibrators and reagents, stable electrical power, highly trained personnel and rapid transportation of samples. Microfluidic systems allow miniaturization and integration of complex functions, which could move sophisticated diagnostic tools out of the developed-world laboratory. These systems must be inexpensive, but also accurate, reliable, rugged and well suited to the medical and social contexts of the developing world.
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              Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging.

              Omid Veiseh, Jonathan W. Gunn, Miqin Zhang (2010)
              Magnetic nanoparticles (MNPs) represent a class of non-invasive imaging agents that have been developed for magnetic resonance (MR) imaging. These MNPs have traditionally been used for disease imaging via passive targeting, but recent advances have opened the door to cellular-specific targeting, drug delivery, and multi-modal imaging by these nanoparticles. As more elaborate MNPs are envisioned, adherence to proper design criteria (e.g. size, coating, molecular functionalization) becomes even more essential. This review summarizes the design parameters that affect MNP performance in vivo, including the physicochemical properties and nanoparticle surface modifications, such as MNP coating and targeting ligand functionalizations that can enhance MNP management of biological barriers. A careful review of the chemistries used to modify the surfaces of MNPs is also given, with attention paid to optimizing the activity of bound ligands while maintaining favorable physicochemical properties. Copyright 2009 Elsevier B.V. All rights reserved.
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                Author and article information

                Journal
                Title: IEEE Communications Surveys & Tutorials
                Abbreviated Title: IEEE Commun. Surv. Tutorials
                Publisher: Institute of Electrical and Electronics Engineers (IEEE)
                ISSN (Electronic): 1553-877X
                Publication date Created: 23 2016
                Publication date (Print): 23 2016
                Volume: 18
                Issue: 3
                Pages: 1887-1919
                Article
                DOI: 10.1109/COMST.2016.2527741
                SO-VID: 9854c916-c223-454c-bc65-ce91bb767af4
                Copyright © © 2016
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