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      Control strategies on mosquitos population for the fight against arboviruses

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          Abstract

          In the fight against vector-borne arboviruses, an important strategy of control of epidemic consists in controlling the population of vector, \textit{Aedes} mosquitoes in this case. Among possible actions, two techniques consist in releasing mosquitoes to reduce the size of the population (Sterile Insect Technique) or in replacing the wild population by a population carrying a bacteria, called \textit{Wolbachia}, blocking the transmission of viruses from mosquitoes to human. This paper is concerned with the question of optimizing the release protocol for these two strategies with the aim of getting as close as possible to the objectives. Starting from a mathematical model describing the dynamics of the population, we include the control function and introduce the cost functional for both \textit{population replacement} and \textit{Sterile Insect Technique} problems. Next, we establish some properties of the optimal control and illustrate them with some numerical simulations.

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          Wolbachia: master manipulators of invertebrate biology.

          Wolbachia are common intracellular bacteria that are found in arthropods and nematodes. These alphaproteobacteria endosymbionts are transmitted vertically through host eggs and alter host biology in diverse ways, including the induction of reproductive manipulations, such as feminization, parthenogenesis, male killing and sperm-egg incompatibility. They can also move horizontally across species boundaries, resulting in a widespread and global distribution in diverse invertebrate hosts. Here, we review the basic biology of Wolbachia, with emphasis on recent advances in our understanding of these fascinating endosymbionts.
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            Wolbachia and cytoplasmic incompatibility in mosquitoes.

            Wolbachia are maternally inherited bacteria that induce cytoplasmic incompatibility in mosquitoes, and are able to use these patterns of sterility to spread themselves through populations. For this reason they have been proposed as a gene drive system for mosquito genetic replacement, as well as for the reduction of population size or for modulating population age structure in order to reduce disease transmission. Here, recent progress in the study of mosquito Wolbachia is reviewed. We now have much more comprehensive estimates of the parameters that can affect the spread of Wolbachia through natural populations from low starting frequencies, and for waves of spread to be maintained in the face of partial barriers to gene flow. In Aedes albopictus these dynamics are extremely favourable, with very high maternal transmission fidelity and levels of incompatibility recorded. Correspondence between measurements taken in the lab and field is much better than in the Drosophila simulans model system. Important research goals are also discussed, including Wolbachia transformation, interspecific transfer and the elucidation of the mechanisms of incompatibility and rescue; all will be aided by a wealth of new Wolbachia genome information.
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              Solving the Wolbachia paradox: modeling the tripartite interaction between host, Wolbachia, and a natural enemy.

              Wolbachia is one of the most common symbionts of arthropods. Its establishment requires lateral transfer to and successful transmission within novel host species. However, Wolbachia performs poorly when introduced into new host species, and models predict that Wolbachia should seldom be able to establish from low initial frequencies. Recently, various symbionts, including Wolbachia, have been shown to protect their hosts from natural enemies. Hence, Wolbachia invasion may be facilitated by the dynamic interaction between it, its host, and a natural enemy. We model such an interaction whereby Wolbachia induces either complete resistance, partial resistance, or tolerance to a host-specific pathogen and also induces the common manipulation phenotype of cytoplasmic incompatibility (CI). We show that the presence of the pathogen greatly facilitates Wolbachia invasion from rare and widens the parameter space in which "imperfect" Wolbachia strains can invade. Furthermore, positive frequency-dependent selection through CI can drive Wolbachia to very high frequencies, potentially excluding the pathogen. These results may explain a poorly understood aspect of Wolbachia biology: it is widespread, despite performing poorly after transfer to new host species. They also support the intriguing possibility that Wolbachia strains that encode both CI and natural-enemy resistance could potentially rid insects, including human disease vectors, of important pathogens.
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                Author and article information

                Journal
                17 January 2019
                Article
                1901.05688
                bab7b538-e49a-4fa3-8eb0-a5fe07a9572b

                http://arxiv.org/licenses/nonexclusive-distrib/1.0/

                History
                Custom metadata
                math.AP math.OC
                ccsd

                Analysis,Numerical methods
                Analysis, Numerical methods

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