581
views
0
recommends
+1 Recommend
1 collections
    0
    shares

      To submit to this journal, click here

      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Human nasal rhinosporidiosis: a case report from Malawi

      case-report
      1 , & , 2
      The Pan African Medical Journal
      The African Field Epidemiology Network
      Rhinosporidiosis, polyps, nose, Malawi

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Rhinosporidiosis is a rare chronic granulomatous disease, characterised by polypous lesions of the mucous membrane. Commonly affects the mucous membrane of the naso-pharynx, conjunctiva and palate. Its causative agent is Rhinosporidium seeberi. The disease is more prevalent in the Indian subcontinent, but remains quite rare in our environment. We hereby present a case description of a 70 year old native Malawian male with a polypoid nasal rhinosporidiosis. Patient presented with long standing history of nasal obstruction and intermittent epistaxis for three years. Diagnosis was confirmed by histopathological examination and he was successfully treated by complete surgical excision. This was a very unusual cause of nasal masses in our setting. Nasal rhinosporidioss lesions may largely mimic other ordinary nasal polyps, it is crucial therefore for clinicians in our region to consider rhinosporidiosis as a differential diagnosis when assessing patients presenting with nasal swellings.

          Related collections

          Most cited references10

          • Record: found
          • Abstract: found
          • Article: not found

          Recent advances in rhinosporidiosis and Rhinosporidium seeberi.

          Rhinosporidiosis and its causative pathogen Rhinosporidium seeberi have been known for over a hundred years. Yet unresolved enigmas in rhinosporidiosis include the mode of infection, mechanisms of spread, mechanisms of immunity, some aspects of histopathology e.g. the significance of transepidermal elimination of sporangia, the cause of the variation in cell infiltration patterns in rhinosporidial tissues and their correlations with immune status, and the absence of the Splendore-Hoeppli reaction which is well-marked in invasive, classical mycoses. This review describes the main features of rhinosporidiosis and discusses recent work which clarifies some of these enigmas. Recent work included in this review are molecular biological classification of R. seeberi among the hydrophilic organisms of the former DRIP clade, establishment of a method for the purification of the developmental stages, and some aspects of the immunology of R. seeberi with reference to mechanisms of immune evasion - antigenic variation, host immunoglobulin binding, immune deviation in relation to the chronicity, recurrence and dissemination seen in rhinosporidiosis. The mechanism of endospore release from the sporangium has been described. Some problems involved in the resolution of enigmas that persist are briefly discussed.
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Patterns of rhinosporidiosis in Sri Lanka: comparison with international data.

            One hundred forty-three cases of rhinosporidiosis, confirmed by smear or biopsy, treated in two major General Hospitals in Sri Lanka over a 14 year period (1995-2009) were analyzed in regard to their epidemiological, clinical, clinicopathological, immunological and microbiological features. Regional variations in incidence, age and sex distribution, bathing history, and histopathology were seen. Lacustrine waters were the commonest probable source of infection (84%). Rivers were a source of Rhinosporidium seeberi in Sri Lanka (11%) and domestic well water was a probable source in 5%. The epidemiological features, clinical presentations and histopathology were similar to those in other series. The antirhinosporidial antibody (mean) titers were IgM--142.1 and IgG--178.5, compatible with rhinosporidiosis of long duration. Mantoux positivity to PPD was found in 65% of normal Sri Lankans, by only 35% of patients with rhinosporidiosis. No outbreaks have been reported in Sri Lanka or India. No animal cases of rhinosporidiosis have been reported in Sri Lanka, although rhinosporidiosis in animals has been repeatedly documented in India.
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Disseminated cutaneous rhinosporidiosis.

              A 48-year-old male patient presented to Skin and VD outpatient with multiple granulomatous growths of different sizes all over the body, including numerous subcutaneous swellings mimicking lipomas of 2 years duration. Two and half years back he was operated for a polypoidal growth of left nostril with subsequent recurrence. Fine needle aspiration cytology and histopathology of the cutaneous lesion confirmed the diagnosis as rhinosporidiosis. We report this rare case of disseminated cutaneous rhinosporidiosis.
                Bookmark

                Author and article information

                Journal
                Pan Afr Med J
                PAMJ
                The Pan African Medical Journal
                The African Field Epidemiology Network
                1937-8688
                18 July 2011
                2011
                : 9
                : 27
                Affiliations
                [1 ]Department of Surgery, Mzuzu Central Hospital, Malawi
                [2 ]Department of Obstetrics and gynaecology, Mzuzu Central Hospital, Malawi
                Author notes
                [& ] Corresponding author: Uledi Sefu, Department of surgery, Mzuzu Central Hospital, Private Bag 209, Luwinga, Mzuzu 2, Malawi
                Article
                PAMJ-09-27
                3215549
                22355433
                c5cebc57-5bfe-4fda-a911-9f076955506a
                © Uledi Sefu et al.

                The Pan African Medical Journal - ISSN 1937-8688. This is an Open Access article distributed under the terms of the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 26 April 2011
                : 23 June 2011
                Categories
                Case Report

                Medicine
                rhinosporidiosis,polyps,nose,malawi
                Medicine
                rhinosporidiosis, polyps, nose, malawi

                Comments

                Comment on this article