Association of Systolic Blood Pressure Elevation With Disproportionate Left Ventricular Remodeling in Very Preterm-Born Young Adults : The Preterm Heart and Elevated Blood Pressure

Key Points

Question

Are left ventricular structure and function in preterm-born adults more susceptible to remodeling in association with blood pressure elevation?

Findings

In this cross-sectional cohort study of 468 adults with cardiac magnetic resonance imaging, left ventricular mass index and mass to end-diastolic volume ratio were greater for each 1–mm Hg elevation in systolic blood pressure in preterm-born adults than in term-born adults, with the greatest rise in those born very and extremely preterm (<32 weeks’ gestation).

Meaning

The findings of this study show that adults born preterm demonstrate greater remodeling in response to systolic blood pressure elevation and may require earlier interventions to prevent cardiovascular disease progression.

Abstract

Importance

Preterm-born individuals have higher blood pressure with an increased risk of hypertension by young adulthood, as well as potentially adverse cardiac remodeling even when normotensive. To what extent blood pressure elevation affects left ventricular (LV) structure and function in adults born preterm is currently unknown.

Objective

To investigate whether changes observed in LV structure and function in preterm-born adults make them more susceptible to cardiac remodeling in association with blood pressure elevation.

Design, Setting, and Participants

This cross-sectional cohort study, conducted at the Oxford Cardiovascular Clinical Research Facility and Oxford Centre for Clinical Magnetic Resonance Research, included 468 adults aged 18 to 40 years. Of these, 200 were born preterm (<37 weeks’ gestation) and 268 were born at term (≥37 weeks’ gestation). Cardiac magnetic resonance imaging was used to characterize LV structure and function, with clinical blood pressure readings measured to assess hypertension status. Demographic and anthropometric data, as well as birth history and family medical history information, were collected. Data were analyzed between January 2012 and February 2021.

Main Outcomes and Measures

Cardiac magnetic resonance measures of LV structure and function in response to systolic blood pressure elevation.

Results

The cohort was primarily White (>95%) with a balanced sex distribution (51.5% women and 48.5% men). Preterm-born adults with and without hypertension had higher LV mass index, reduced LV function, and smaller LV volumes compared with term-born individuals both with and without hypertension. In regression analyses of systolic blood pressure with LV mass index and LV mass to end-diastolic volume ratio, there was a leftward shift in the slopes in preterm-born compared with term-born adults. Compared with term-born adults, there was a 2.5-fold greater LV mass index per 1–mm Hg elevation in systolic blood pressure in very and extremely preterm-born adults (<32 weeks’ gestation) (0.394 g/m ² vs 0.157 g/m ² per 1 mm Hg; P < .001) and a 1.6-fold greater LV mass index per 1–mm Hg elevation in systolic blood pressure in moderately preterm-born adults (32 to 36 weeks’ gestation) (0.250 g/m ² vs 0.157 g/m ² per 1 mm Hg; P < .001). The LV mass to end-diastolic volume ratio per 1–mm Hg elevation in systolic blood pressure in the very and extremely preterm-born adults was 3.4-fold greater compared with those born moderately preterm (3.56 × 10 ⁻³ vs 1.04 × 10 ⁻³ g/mL per 1 mm Hg; P < .001) and 3.3-fold greater compared with those born at term (3.56 × 10 ⁻³ vs 1.08 × 10 ⁻³ g/mL per 1 mm Hg; P < .001).

Conclusions and Relevance

Preterm-born adults have a unique LV structure and function that worsens with systolic blood pressure elevation. Additional primary prevention strategies specifically targeting cardiovascular risk reduction in this population may be warranted.

Abstract

This study investigates whether changes observed in left ventricular structure and function in preterm-born adults make them more susceptible to cardiac remodeling in association with blood pressure elevation.