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Abstract
Treatment of cancer of the retromolar trigone (RMT) is controversial. While early
lesions may be managed with single-modality, more advanced lesions may invade the
mandible, pterygoid musculature, and the adjacent mucosa of the tonsillar pillar and
soft palate, therefore making therapeutic decisions more complicated. Treatment options
traditionally include surgical resection, external beam irradiation, and combined
modality therapy. The choice of therapy is dependent on the extent of the tumor, nodal
metastasis, and the medical status of the patient and comorbid conditions. The following
review outlines the current issues relevant to the diagnosis and therapy of patients
with RMT malignancy.