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Club Cell Protein 16 (CC16) Augmentation: A Potential Disease-modifying Approach for Chronic Obstructive Pulmonary Disease (COPD).
Maria E Laucho-Contreras
1 ,
Francesca Polverino
1
,
2
,
3 ,
Yohannes Tesfaigzi
2 ,
Aprile Pilon
4 ,
Bartolome R Celli
1
,
2 ,
Caroline A Owen
1
,
2
Jul 2016
Bronchoalveolar lavage fluid,
CC10,
CC16,
COPD,
Club cells,
chronic bronchitis,
emphysema,
formyl peptide receptor-2,
lipoxin A4,
lung inflammation,
nuclear factor kappa B,
phospholipase A2,
recombinant therapy,
secretoglobin 1A1,
serum amyloid A,
small airway remodeling,
toll-like receptor,
uteroglobin
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Abstract
Club cell protein 16 (CC16) is the most abundant protein in bronchoalveolar lavage fluid. CC16 has anti-inflammatory properties in smoke-exposed lungs, and chronic obstructive pulmonary disease (COPD) is associated with CC16 deficiency. Herein, we explored whether CC16 is a therapeutic target for COPD.
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Author and article information
Bronchoalveolar lavage fluid, CC10, CC16, COPD, Club cells, chronic bronchitis, emphysema, formyl peptide receptor-2, lipoxin A4, lung inflammation, nuclear factor kappa B, phospholipase A2, recombinant therapy, secretoglobin 1A1, serum amyloid A, small airway remodeling, toll-like receptor, uteroglobin