MATH+ protocol for the treatment of SARS-CoV-2 infection: the scientific rationale.

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Abstract

COVID-19 disease progresses through a number of distinct phases. The management of each phase is unique and specific. The pulmonary phase of COVID-19 is characterized by an organizing pneumonia with profound immune dysregulation, activation of clotting, and a severe microvascular injury culminating in severe hypoxemia. The core treatment strategy to manage the pulmonary phase includes the combination of methylprednisolone, ascorbic acid, thiamine, and heparin (MATH+ protocol). The rationale for the MATH+ protocol is reviewed in this paper.

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Journal

Journal ID (iso-abbrev): Expert Rev Anti Infect Ther

Title: Expert review of anti-infective therapy

Publisher: Informa UK Limited

ISSN (Electronic): 1744-8336

ISSN (Print): 1478-7210

Publication date (Electronic): February 2021

Volume: 19

Issue: 2

Affiliations

[1 ] Division of Pulmonary and Critical Care Medicine, Eastern Virginia Medical School , Norfolk, VA, USA.

[2 ] Trauma and Life Support Center, Critical Care Service, University of Wisconsin School of Medicine and Public Health , Madison, WI, USA.

[3 ] Department of Critical Care Medicine, United Memorial, Medical Center , Houston, TX, USA.

[4 ] Department of Nephrology and Critical Care, Hackensack Meridian School of Medicine at Seton Hall University , Nutley, NJ, USA.

[5 ] Department of Nephrology and Critical Care, Community Medical Center , Toms River, NJ, USA.

[6 ] Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Tennessee Health Science Center , Memphis, TN, USA.

[7 ] Memphis Veterans Affairs Medical Center , Memphis, TN, USA.

Article

DOI: 10.1080/14787210.2020.1808462

PubMed ID: 32809870

SO-VID: 67af79b8-d3b2-478a-b13d-be26cf0bd63c

History

Keywords: methylprednisolone,heparin,ascorbic acid,COVID-19

Data availability:

Keywords: methylprednisolone, heparin, ascorbic acid, COVID-19

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