TCF21 rs12190287 Polymorphisms Are Associated with Ventricular Septal Defects in a Chinese Population.

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Abstract

TCF21 knockout mice display cardiac defects, including ventricular septal defects (VSDs). Functional rs12190287 polymorphisms located within the 3' untranslated region (3'-UTR) of TCF21 were associated with a risk of coronary heart disease in the European and Eastern populations. However, whether rs12190287 polymorphisms in the TCF21-3'UTR confer predisposition to congenital heart disease (CHD) is unclear.

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Author and article information

Journal

Journal ID (iso-abbrev): Genet Test Mol Biomarkers

Title: Genetic testing and molecular biomarkers

Publisher: Mary Ann Liebert Inc

ISSN (Electronic): 1945-0257

ISSN (Print): 1945-0257

Publication date (Electronic): May 2017

Volume: 21

Issue: 5

Affiliations

[1 ] 1 Department of Cardiovascular Surgery, Union Hospital, Fujian Medical University , Fuzhou, China .

[2 ] 2 Department of Genetics, National Research Institute for Family Planning , Beijing, China .

[3 ] 3 CAS Key Laboratory of Genome Sciences and Information, Chinese Academy of Sciences, Beijing Institute of Genomics , Beijing, China .

[4 ] 4 Graduat e School of Peking Union Medical College , Beijing, China .

Article

DOI: 10.1089/gtmb.2016.0324

PubMed ID: 28346832

SO-VID: b148a9e3-d711-46b3-89c3-acd33ffe10a2

History

Keywords: TCF21,rs12190287,susceptibility,ventricular septal defect

Data availability:

Keywords: TCF21, rs12190287, susceptibility, ventricular septal defect

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