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      Cardiac Cachexia Associated With Valvular Heart Failure

      case-report
      1 , 2 , , 3
      ,
      Cureus
      Cureus
      tavr, aortic stenosis, valvulopathy, heart failure, cardiac cachexia

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          Abstract

          Cardiac cachexia (CC) represents a serious complication of heart failure (HF). This condition could be directly related to mortality. The weight or muscle mass loss has to be monitored in our patients with HF to avoid potential complications.

          We report a case of an elderly patient with a history of aortic stenosis (AS) who presented with progressive shortness of breath limiting his daily activities associated with weight loss. Signs of heart failure were evident on physical examination, and valvulopathy was also evident. His echocardiogram showed reduced ejection fraction (EF) with structural changes and severe aortic stenosis. He was not a candidate for cardiothoracic surgery, and a transcatheter aortic valve replacement (TAVR) was performed. After the procedure, his symptoms improved, and during the outpatient follow-up, his cardiac function and dry weight improved.

          Cardiac cachexia could be caused by reversible cardiomyopathy. Early assessment and approach are critical for the outcome of our patients, impacting their quality of life and outcome in terms of morbidity and mortality consequences.

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          Most cited references43

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          Cachexia: a new definition.

          On December 13th and 14th a group of scientists and clinicians met in Washington, DC, for the cachexia consensus conference. At the present time, there is no widely agreed upon operational definition of cachexia. The lack of a definition accepted by clinician and researchers has limited identification and treatment of cachectic patient as well as the development and approval of potential therapeutic agents. The definition that emerged is: "cachexia, is a complex metabolic syndrome associated with underlying illness and characterized by loss of muscle with or without loss of fat mass. The prominent clinical feature of cachexia is weight loss in adults (corrected for fluid retention) or growth failure in children (excluding endocrine disorders). Anorexia, inflammation, insulin resistance and increased muscle protein breakdown are frequently associated with cachexia. Cachexia is distinct from starvation, age-related loss of muscle mass, primary depression, malabsorption and hyperthyroidism and is associated with increased morbidity. While this definition has not been tested in epidemiological or intervention studies, a consensus operational definition provides an opportunity for increased research.
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            Gender differences in coronary heart disease.

            Cardiovascular disease develops 7 to 10 years later in women than in men and is still the major cause of death in women. The risk of heart disease in women is often underestimated due to the misperception that females are 'protected' against cardiovascular disease. The under-recognition of heart disease and differences in clinical presentation in women lead to less aggressive treatment strategies and a lower representation of women in clinical trials. Furthermore, self-awareness in women and identification of their cardiovascular risk factors needs more attention, which should result in a better prevention of cardiovascular events. In this review we summarise the major issues that are important in the diagnosis and treatment of coronary heart disease in women. (Neth Heart J 2010;18:598-603.).
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              Left ventricular hypertrophy: pathogenesis, detection, and prognosis.

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                Author and article information

                Journal
                Cureus
                Cureus
                2168-8184
                Cureus
                Cureus (Palo Alto (CA) )
                2168-8184
                2 December 2021
                December 2021
                : 13
                : 12
                : e20109
                Affiliations
                [1 ] Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, New York, USA
                [2 ] Internal Medicine, BronxCare Health System, Icahn School of Medicine at Mount Sinai, New York, USA
                [3 ] Cardiology, BronxCare Health System, Icahn School of Medicine at Mount Sinai, New York, USA
                Author notes
                Article
                10.7759/cureus.20109
                8723726
                e310bb34-6d83-44a2-a96a-be2dda6df26e
                Copyright © 2021, Rodriguez-Guerra et al.

                This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

                History
                : 1 December 2021
                Categories
                Cardiology
                Internal Medicine

                tavr,aortic stenosis,valvulopathy,heart failure,cardiac cachexia

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