Preclinical evaluation of the novel small-molecule integrin alpha5beta1 inhibitor JSM6427 in monkey and rabbit models of choroidal neovascularization.

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Abstract

To evaluate the pharmacologic activity and tolerability of JSM6427, a potent and first selective small-molecule inhibitor of integrin alpha5beta1, in monkey and rabbit models of choroidal neovascularization (CNV).

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Journal

Journal ID (iso-abbrev): Arch. Ophthalmol.

Title: Archives of ophthalmology (Chicago, Ill. : 1960)

Publisher: American Medical Association (AMA)

ISSN (Electronic): 1538-3601

ISSN (Print): 0003-9950

Publication date (Electronic): Oct 2009

Volume: 127

Issue: 10

Affiliations

[1 ] Jerini AG, Invalidenstrasse 130, 10115 Berlin, Germany. grit.zahn@gmx.net

Article

Publisher Item ID: 127/10/1329

DOI: 10.1001/archophthalmol.2009.265

PubMed ID: 19822850

SO-VID: f5777d9e-50f8-4325-8a7a-20eed8cc77d4

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