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      Autophagy fights disease through cellular self-digestion.

      Nature
      Aging, physiology, Animals, Autophagy, immunology, Cell Death, Cell Survival, Humans, Immunity, Innate, Neoplasms, pathology, Neurodegenerative Diseases

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          Abstract

          Autophagy, or cellular self-digestion, is a cellular pathway involved in protein and organelle degradation, with an astonishing number of connections to human disease and physiology. For example, autophagic dysfunction is associated with cancer, neurodegeneration, microbial infection and ageing. Paradoxically, although autophagy is primarily a protective process for the cell, it can also play a role in cell death. Understanding autophagy may ultimately allow scientists and clinicians to harness this process for the purpose of improving human health.

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          Author and article information

          Journal
          18305538
          2670399
          10.1038/nature06639

          Chemistry
          Aging,physiology,Animals,Autophagy,immunology,Cell Death,Cell Survival,Humans,Immunity, Innate,Neoplasms,pathology,Neurodegenerative Diseases

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