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      Method of administration determines the effect of naloxone on pain.

      Brain Research

      Analgesics, administration & dosage, Double-Blind Method, Humans, Injections, Intravenous, instrumentation, methods, Naloxone, Pain, Postoperative, drug therapy, Tooth Extraction, Tooth, Impacted, surgery

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          Abstract

          The opiate antagonist, naloxone, produces dose-dependent biphasic changes in clinical pain. The mechanism of the analgesia produced by low dose naloxone is unknown. To study the analgesic effect of naloxone, we have used a programmable infusion pump, which eliminates placebo-induced endorphin-mediated analgesia, to administer different doses of naloxone. We report that use of machine infusion of naloxone exclusively produces analgesia. The implications of this finding to the mechanism of naloxone-induced analgesia are discussed.

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          3948000

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